Medical counter measures including dry powder formulations and associated methods
AssigneeBelhaven BioPharma Inc.
InventorsScott Lyman, Barry Bleske
Life of this patent
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Abstract
Provided herein are dry powder formulations comprising at least one active pharmaceutical ingredient suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including respiratory conditions, hemodynamic collapse, seizures, migraines, and other conditions.
Claims20
A device for intranasal administration of a pharmaceutical composition comprising:
- a reservoir and a means for discharging one or more doses of the pharmaceutical composition, wherein the reservoir contains a quantity of the pharmaceutical composition;
- wherein the pharmaceutical composition is a dry powder comprising:
- galantamine or a pharmaceutical salt thereof, wherein the pharmaceutical composition provides a dose of about 5 mg to about 75 mg of the galantamine or the pharmaceutical salt thereof;
- sodium chloride, wherein the pharmaceutical composition comprises about 0.01 mg to about 5 mg of the sodium chloride;
- and
- a carrier;
- wherein the pharmaceutical composition does not include chitosan.
A kit for intranasal administration of a pharmaceutical composition comprising:
- at least one device, wherein each of the at least one device includes a reservoir and a means for discharging one or more doses of the pharmaceutical composition, wherein the reservoir contains a quantity of the pharmaceutical composition;
- and
- a pouch and/or a hard case;
- wherein the pharmaceutical composition is a dry powder comprising:
- galantamine or a pharmaceutical salt thereof, wherein the pharmaceutical composition provides a dose of about 5 mg to about 75 mg of the galantamine or the pharmaceutical salt thereof;
- sodium chloride, wherein the pharmaceutical composition comprises about 0.01 mg to about 5 mg of the sodium chloride;
- and
- a carrier;
- wherein the pharmaceutical composition does not include chitosan.
A device for intranasal administration of a pharmaceutical composition comprising:
- a reservoir and a means for discharging one or more doses of the pharmaceutical composition, wherein the reservoir contains a quantity of the pharmaceutical composition;
- wherein the pharmaceutical composition is a dry powder comprising:
- galantamine or a pharmaceutical salt thereof, wherein the pharmaceutical composition provides a dose of the galantamine or the pharmaceutical salt thereof;
- memantine, wherein the pharmaceutical composition provides a dose of about 1 mg to about 30 mg of the memantine;
- sodium chloride, wherein the pharmaceutical composition comprises about 0.01 mg to about 5 mg of the sodium chloride;
- and
- a carrier;
- wherein the pharmaceutical composition does not include chitosan.
Dependencies are inferred from the claim text.