Nasal administration

A method of treating chronic rhinosinusitis without nasal polyps in a patient comprising:

• placing a nosepiece of a housing into a first nostril of the patient;
• placing a mouthpiece of the housing into a mouth of the patient, the mouthpiece being fluidly connected to the nosepiece by a flow path, wherein exhalation by the patient into the mouthpiece and out of the nosepiece produces a bi-directional fluid flow of exhalation air into a first nasal passageway of the patient and out of a second nasal passageway of the patient;
• manually depressing a chamber with the patient's thumb or finger to activate a pump and flow fluticasone propionate from the chamber to the nosepiece;
• opening a valve in the flow path from the mouthpiece to the nosepiece in response to manually depressing the chamber;
• administering fluticasone propionate as a liquid aerosol during exhalation by the patient through the nosepiece;
• delivering carbon dioxide during exhalation by the patient through the nosepiece, to a location at an upper posterior region of the first nasal passageway of the patient;
• and
• reducing a pH at the location at the upper posterior region of the first nasal passageway of the patient by an amount ranging from about 0.1 pH units to about 0.2 pH units by controlling the fluid flow to deliver the carbon dioxide at a concentration of from about 5% vol/vol to about 6% vol/vol carbon dioxide and at a fluid flow rate of at least 20 L/min for a duration of from about 2 seconds to about 3 seconds, wherein the carbon dioxide is delivered before or at the same time as the fluticasone propionate.

A method of treating chronic rhinosinusitis with nasal polyps in a patient comprising:

• placing a nosepiece of a housing into a first nostril of the patient;
• placing a mouthpiece of the housing into a mouth of the patient, the mouthpiece being fluidly connected to the nosepiece by a flow path, wherein exhalation by the patient into the mouthpiece and out of the nosepiece produces a bi-directional fluid flow of exhalation air into a first nasal passageway of the patient and out of a second nasal passageway of the patient;
• manually depressing a chamber with the patient's thumb or finger to activate a pump and flow fluticasone propionate from the chamber to the nosepiece,
• wherein the manually depressing of the chamber further comprises axially moving the chamber within an aperture in the housing;
• opening a valve in the flow path from the mouthpiece to the nosepiece in response to manually depressing the chamber;
• administering fluticasone propionate as a liquid aerosol during exhalation by the patient through the nosepiece;
• delivering carbon dioxide during exhalation by the patient through the nosepiece, to a location at an upper posterior region of the first nasal passageway of the patient;
• and
• reducing a pH at the location at the upper posterior region of the first nasal passageway of the patient by an amount ranging from about 0.1 pH units to about 0.2 pH units by controlling the fluid flow to deliver the carbon dioxide at a concentration of from about 5% vol/vol to about 6% vol/vol carbon dioxide and at a fluid flow rate of at least 20 L/min for a duration of from about 2 seconds to about 3 seconds, wherein the carbon dioxide is delivered before or at the same time as the fluticasone propionate, wherein:
• the chamber, pump and nosepiece are axially aligned;
• the flow path includes a delivery channel which inwardly tapers as the delivery channel extends from the valve towards the nosepiece;
• and
• the administering of the fluticasone propionate further comprises simultaneously delivering the fluticasone propionate and exhalation air to the first nasal passageway.

A method of treating chronic rhinosinusitis without nasal polyps in a patient comprising:

• placing a nosepiece of a housing into a first nostril of the patient;
• placing a mouthpiece of the housing into a mouth of the patient, the mouthpiece being fluidly connected to the nosepiece by a flow path, wherein exhalation by the patient into the mouthpiece and out of the nosepiece produces a bi-directional fluid flow of exhalation air into a first nasal passageway of the patient and out of a second nasal passageway of the patient;
• manually depressing a chamber with the patient's thumb or finger to activate a pump and flow fluticasone propionate from the chamber to the nosepiece,
• wherein the manually depressing of the chamber further comprises axially moving the chamber within an aperture in the housing;
• opening a valve in the flow path from the mouthpiece to the nosepiece in response to manually depressing the chamber;
• administering fluticasone propionate as a liquid aerosol during exhalation by the patient through the nosepiece;
• delivering carbon dioxide during exhalation by the patient through the nosepiece, to a location at an upper posterior region of the first nasal passageway of the patient;
• and
• reducing a pH at the location at the upper posterior region of the first nasal passageway of the patient by an amount ranging from about 0.1 pH units to about 0.2 pH units by controlling the fluid flow to deliver the carbon dioxide at a concentration of from about 5% vol/vol to about 6% vol/vol carbon dioxide and at a fluid flow rate of at least 20 L/min for a duration of from about 2 seconds to about 3 seconds, wherein the carbon dioxide is delivered before or at the same time as the fluticasone propionate, wherein:
• the chamber, pump and nosepiece are axially aligned;
• the flow path includes a delivery channel which inwardly tapers as the delivery channel extends from the valve towards the nosepiece;
• and
• the administering of the fluticasone propionate further comprises simultaneously delivering the fluticasone propionate and exhalation air to the first nasal passageway.