Tubular nonwoven structure as active agent carrier for the atraumatic treatment of hollow organs, and a process for producing the same

Tubular nonwoven structure as a carrier of an active agent, hereinafter referred to as a tubular sleeve, for atraumatic treatment of hollow organs, for application via a balloon catheter,

• wherein the tubular sleeve is folded about a longitudinal sleeve axis in an initial state and can be unfolded in a final state for attachment to an inner wall of a hollow organ, and the folding of the tubular sleeve is directed as pleating around the longitudinal sleeve axis,
• wherein the tubular sleeve is formed of areal zones comprising a plurality of first biodegradable polymer nanofibers and areal zones comprising a plurality of second biodegradable polymer nanofibers,
• wherein a medicinal active agent is incorporated into the plurality of first biodegradable polymer nanofibers and/or is arranged in interspaces between the plurality of first biodegradable polymer nanofibers, and
• wherein the areal zones comprising the plurality of first biodegradable polymer nanofibers are formed in such a way that the plurality of first biodegradable polymer nanofibers degrades over an adjustable period of time of 2 weeks to 3 months so that the active agent can be delivered to a hollow organ wall in this period of time, and the plurality of first biodegradable polymer nanofibers degrades more slowly than the plurality of second biodegradable polymer nanofibers, and the areal zones comprising the plurality of first biodegradable polymer nanofibers form microflakes which are in coherence with the areal zones comprising the plurality of second biodegradable polymer nanofibers.