Composite ultrathin coating film with inhibitory activity against hyperinflammatory response and bacteria, implant including same, and preparation method therefor
AssigneeThe Industry & Academic Cooperation in Chungnam National University (IAC)
InventorsSung Yun Yang, Su Jin Lee, Dong Woon Kim, Sang-Ha Oh
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Abstract
A composite ultra-thin coating film with hypersensitivity inflammatory reaction inhibition and antibacterial activity, an implant comprising the same, and a method for preparing the same are described. The composite ultra-thin coating film can be applied to medical silicone-based polymers and exhibits excellent antibacterial activity and inhibits deformed cell proliferation so that hypertrophic tissue is not formed and there is no cytotoxicity.
Claims15
A composite ultra-thin coating film comprising:
- an inner layer in which materials selected from the group consisting of a hyaluronic acid polymer (HA), a polymer represented by the following Formula 1, and poly(allylamine hydrochloride) (PAH) are alternately laminated;
- and
- an outermost layer in contact with cells,
- wherein the outermost layer is laminated with a hyaluronic acid polymer (HA) or a polymer represented by the following Formula 1:
- where,
- *refers to a part that is combined,
- n, m, and o are the same as or different from each other and are each independently an integer of 1 to 100,
- L1 to L8 are the same as or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms, and
- X1 to X3 are the same as or different from each other, and are each independently selected from the group consisting of cyclodextrin, a compound represented by Formula 2 above, and a compound represented by Formula 3 above.
A method for preparing a composite ultra-thin coating film comprising steps of:
- forming an inner layer by alternately laminating materials selected from the group consisting of a hyaluronic acid polymer (HA), a polymer represented by the following Formula 1, and poly(allylamine hydrochloride) (PAH);
- and
- forming an outermost layer in contact with cells by laminating the hyaluronic acid polymer (HA) or the polymer represented by the following Formula 1:
- where,
- *refers to a part that is combined,
- n, m, and o are the same as or different from each other and are each independently an integer of 1 to 100,
- L1 to L8 are the same as or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms, and
- X1 to X3 are the same as or different from each other, and are each independently selected from the group consisting of cyclodextrin, a compound represented by Formula 2 above, and a compound represented by Formula 3 above.
A method for manufacturing an implant on which a composite ultra-thin coating film is formed comprising steps of:
- forming an inner layer by alternately laminating materials selected from the group consisting of a hyaluronic acid polymer (HA), a polymer represented by the following Formula 1, and poly(allylamine hydrochloride) (PAH) on a substrate;
- and
- forming an outermost layer in contact with cells by laminating the hyaluronic acid polymer (HA) or the polymer represented by the following Formula 1:
- where,
- * refers to a part that is combined,
- n, m, and o are the same as or different from each other and are each independently an integer of 1 to 100,
- L1 to L8 are the same as or different from each other, and are each independently a single bond or a substituted or unsubstituted alkylene group having 1 to 10 carbon atoms, and
- X1 to X3 are the same as or different from each other, and are each independently selected from the group consisting of cyclodextrin, a compound represented by Formula 2 above, and a compound represented by Formula 3 above.
Dependencies are inferred from the claim text.