Silicone polyurea block copolymer coating compositions and methods
AssigneeInnovative Surface Technologies, Inc.
InventorsKristin Taton, Patrick Guire, Charles Leir
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Abstract
Silicone polyurea block copolymers are prepared by copolymerizing: (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; (b) a monofunctional silicone isocyanate; and (c) a diisocyanate. Compositions useful as passivating coatings comprising the block copolymer are also provided, and substrates coated with the compositions. Methods of preparing and using the compositions are also described.
Claims20
A non-implanted medical device having a surface containing a passivating coating, the passivating coating comprising a silicone polyurea copolymer having a polymer backbone and comprising a reaction product of:
- (a) a diamine composition comprising a polyethylene glycol diamine compound having a formula (I), (II), or a combination of (I) and (II):
- wherein y is an integer in the range of 2 to 40, and x+z is an integer in the range of 1 to 8;
- or
- wherein n is an integer in the range of 1 to 100;
- (b) a monofunctional silicone isocyanate compound having a formula:
- wherein D is an alkyl radical having 1 to 6 carbon atoms,
- G is a bivalent alkyl radical having 1 to 6 carbon atoms,
- each R is independently selected from a monovalent alkyl radical having about 1 to about 12 carbon atoms, a substituted alkyl radical having about 1 to about 12 carbon atoms, a phenyl radical and a substituted phenyl radical, and
- m is an integer in the range of 15 to 300;
- and
- (c) a diisocyanate compound, wherein the silicone polyurea copolymer comprises total isocyanate groups to total amine groups in a molar ratio of 1.5:1 to 1.05:1.
A medical device fabricated of a material selected from silicone, polystyrene, polyethylene terephthalate, polyethylene, polyvinyl chloride, polypropylene, polyurethane, polytetrafluoroethylene, polyamide, polyolefin, or copolymers or combinations thereof,
- the device having a surface containing a dry lubricious coating, the dry lubricious coating comprising a silicone polyurea copolymer having a polymer backbone and comprising a reaction product of:
- (a) a diamine composition comprising a polyethylene glycol diamine compound having a formula (I), (II), or a combination of (I) and (II):
- wherein y is an integer in the range of 2 to 40, and x+z is an integer in the range of 1 to 8;
- or
- wherein n is an integer in the range of 1 to 100;
- (b) a monofunctional silicone isocyanate compound having a formula:
- wherein D is an alkyl radical having 1 to 6 carbon atoms,
- G is a bivalent alkyl radical having 1 to 6 carbon atoms,
- each R is independently selected from a monovalent alkyl radical having about 1 to about 12 carbon atoms, a substituted alkyl radical having about 1 to about 12 carbon atoms, a phenyl radical and a substituted phenyl radical, and
- m is an integer in the range of 15 to 300;
- and
- (c) a diisocyanate compound, wherein the silicone polyurea copolymer comprises total isocyanate groups to total amine groups in a molar ratio of 1.5:1 to 1.05:1,
- wherein the dry lubricous coating provides the medical device with reduced frictional resistance against an uncoated substrate as compared to an uncoated medical device or medical article.
Dependencies are inferred from the claim text.