Method for manufacturing bone-regeneration material comprising biodegradable fibers by using electrospinning method
AssigneesNational University Corporation Nagoya Institute of Technology, Orthorebirth Co., Ltd.
InventorsToshihiro Kasuga, Yasutoshi Nishikawa
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Abstract
A bone-regeneration material comprising a biodegradable fiber produced using an electrospinning process, wherein the biodegradable fiber comprises 30 to 50 wt % of PLLGA resin and 70 to 50 wt % of β-TCP fine particles substantially uniformly dispersed in the PLLGA resin without forming aggregates, wherein the β-TCP fine particles are not chemically bonded to the PLLGA resin, and surroundings of the β-TCP fine particles are covered by the PLLGA resin so that the β-TCP fine particles are not separated from the biodegradable fiber during a formation of the fiber, and wherein the bone-regeneration material is sterilized by using radiation sterilization with gamma ray.
Claims6
A bone-regeneration material comprising a biodegradable fiber produced using an electrospinning process,
- wherein the biodegradable fiber comprises 30 to 50 wt % of a copolymer of poly-L-lactic acid and polyglycolic acid (PLLGA) resin and 70 to 50 wt % of phase tricalcium phosphate (β-TCP) fine particles substantially uniformly dispersed in the PLLGA resin without forming aggregates,
- wherein the β-TCP fine particles are not chemically bonded to the PLLGA resin, and surroundings of the β-TCP fine particles are covered by the PLLGA resin so that the β-TCP fine particles are not separated from the biodegradable fiber during a formation of the fiber, and
- wherein the bone-regeneration material is has been sterilized by gamma radiation.
Dependencies are inferred from the claim text.