Methods for treatment of psoriasis with an anti-oxLDL antibody
AssigneeAbcentra, LLC
InventorsBertrand C. Liang, Stacey Ruiz, Christopher John Farina
Life of this patent
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Abstract
Compositions and methods for treating a subject with psoriasis are provided, including an inhibitor of oxidized low density lipoprotein (LDL), malondialdehyde-modified epitope in LDL or native LDL for administration. Exemplary inhibitors of oxidized or malondialdehyde-modified LDL include orticumab, a variant antibody or peptides capable of binding oxidized or malondialdehyde-modified LDL, which results in improvement in conditions of psoriasis even in patients that are refractory to ultraviolet A/B therapy and topical steroids.
Claims18
A method for treating, reducing the severity of, slowing progression of, or inhibiting psoriasis or psoriatic arthritis in a subject in need thereof, comprising:
- administering to the subject an effective amount of an antibody or antibody fragment
- comprising a heavy chain determining region (HCDR) 1 having the sequence of SEQ ID NO:
- 2, an HCDR 2 having the sequence of SEQ ID NO:
- 3, and an HCDR 3 having the sequence of SEQ ID NO:
- 4, a light chain determining region (LCDR) 1 having a sequence of SEQ ID NO:
- 5, an LCDR 2 having a sequence of SEQ ID NO:
- 6, and an LCDR 3 having a sequence of SEQ ID NO:
- 7.
A method for passive immunization of a subject, wherein a therapeutically effective amount of an antibody or antibody fragment is administered for treatment of psoriasis or psoriatic arthritis, wherein the antibody comprises an HCDR 1 having the sequence of SEQ ID NO:
- 2, an HCDR 2 having the sequence of SEQ ID NO:
- 3, and an HCDR 3 having the sequence of SEQ ID NO:
- 4, an LCDR 1 having a sequence of SEQ ID NO:
- 5, an LCDR 2 having a sequence of SEQ ID NO:
- 6, and an LCDR 3 having a sequence of SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.