Streptococcal GlcNAc-lacking glycopolypeptides, cell wall carbohydrates, streptococcus vaccines, and methods for making and using them
AssigneeThe Regents of the University of California
InventorsVictor Nizet, Nina van Sorge
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Abstract
In alternative embodiments, the invention provides vaccines, pharmaceutical compounds and formulations for diagnosing, preventing, treating or ameliorating Group A Streptococcus (GAS), Group C Streptococcus (GCS), or Group A Streptococcus (GGS), infections, or other pathogenic Streptococcus infections. In alternative embodiments, the invention provides compositions such as diagnostic tests, assays, immunoassays and test strips, and methods, for detecting or diagnosing the presence of a Streptococcal infection, e.g., Group A Streptococcus (GAS), Group C Streptococcus (GCS), or Group A Streptococcus (GGS), infections, or other pathogenic Streptococcus infections.
Claims12
A glycoconjugate composition comprising an isolated Group A Streptococcus (GAS) cell wall carbohydrate conjugated to a GAS protein, wherein the GAS cell wall carbohydrate comprises a polyrhamnose backbone completely lacking its N-acetyl-D-glucosamine side chain.
Dependencies are inferred from the claim text.