Therapeutic combination comprising a pulmonary surfactant and a steroid for the prophylaxis of BPD
AssigneesChildren's Hospital Medical Center, Saint Louis University School of Medicine, Women and Infants Research Foundation
InventorsAlan Jobe, Augusto Schmidt, Noah Hillman, Matthew Kemp
Life of this patent
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Abstract
Administering a pulmonary surfactant and a corticosteroid in a low dose is effective for the prophylaxis of bronchopulmonary dysplasia (BPD) in preterm neonates.
Claims17
A method for the prophylaxis of bronchopulmonary dysplasia (BPD) in a preterm neonate, comprising administering to a preterm neonate poractant alfa in a dose of 200 mg/kg of body weight of said neonate and budesonide in a dose of 0.1 mg/kg of body weight of said neonate,
- wherein said poractant alfa and budesonide are administered from the 1st to the 4th day of life of the preterm neonate.
A method of reducing lung inflammation in a pre-term neonate treated with mechanical ventilation, comprising the step of administering a composition to said pre-term neonate, wherein said administration occurs during, before, or after said mechanical ventilation, and wherein the composition comprises:
- (a) poractant alfa in a dose of 200 mg/kg of body weight of said neonate;
- in combination with
- (b) budesonide in a dose of 0.1 mg/kg of body weight of said neonate.
Dependencies are inferred from the claim text.