Compositions and methods of controlling expression of thermogenin (UCP-1) in skeletal muscles
AssigneeRaul Bastarrachea
InventorRaul Bastarrachea
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Abstract
Described herein are pharmaceutical compositions containing genes encoding a positive regulatory domain zinc finger protein 16, a peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein, and a bone morphogenetic protein 7. Also disclosed are methods of treating or managing obesity and diabetes by delivering these pharmaceutical compositions using ultrasound-targeted microbubble destruction.
Claims8
A pharmaceutical composition, comprising three expression cassettes capable of inducing UCP-1 expression, wherein:
- the composition is formulated for delivery to a skeletal muscle cell in a mammal;
- a first non-viral nucleic acid construct with a first expression cassette encodes a positive regulatory domain zinc finger protein 16;
- a second non-viral nucleic acid construct with a second expression cassette encodes a peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein;
- and
- a third non-viral nucleic acid construct with a third expression cassette encodes a bone morphogenetic protein 7.
A pharmaceutical composition, comprising a non-viral expression vector containing three expression cassettes capable of inducing UCP-1 expression, wherein:
- the composition is formulated for delivery to a skeletal muscle cell in a mammal;
- a first expression cassette encoding a positive regulatory domain zinc finger protein 16;
- a second expression cassette encoding a peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein;
- and
- a third expression cassette encoding a bone morphogenetic protein 7.
Dependencies are inferred from the claim text.