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US 12,616,712 B2Granted
Sting agonist comprising exosomes for treating neuroimmunological disorders
AssigneeLonza Sales AG
InventorAjay Verma
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Abstract
Provided herein are compositions comprising EV, e.g., exosome, which comprises STING agonists and methods of using such compositions for the treatment of neuroimmunological disorders. Methods of producing the compositions (e.g., EVs comprising a STING agonist) described herein are also provided.
Claims22
A method of treating a glioblastoma multiforme in a subject in need thereof comprising administering to the subject a composition comprising an extracellular vesicle EV and a stimulator of interferon genes protein STING agonist, wherein the EV overexpresses a Scaffold X protein selected from the group consisting of:
- prostaglandin F2 receptor negative regulator PTGFRN, basigin BSG, immunoglobulin superfamily member 2 IGSF2, immunoglobulin superfamily member 3 IGSF3, immunoglobulin superfamily member 8 IGSF8, integrin beta-1 ITGB1, integrin alpha-4 ITGA4, 4F2 cell-surface antigen heavy chain SLC3A2, ATP transporter protein, and wherein the Scaffold X protein is a whole protein or a fragment thereof.
Dependencies are inferred from the claim text.