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US 12,616,710 B2Granted
Topical compositions
AssigneeBausch Health Ireland Limited
InventorsVarsha Bhatt, Radhakrishnan Pillai, Arturo Angel
Life of this patent
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Abstract
The disclosure provides a topical gel formulation comprising 1-1.5 wt. % clindamycin phosphate, 2.5-3.5 wt. % benzoyl peroxide, and 0.1-0.2 wt. % adapalene, in combination with a gelling agent, a polyhydric alcohol, and water, useful in treating inflammatory skin conditions, including acne, together with methods of making and using the same.
Claims4
A topical gel formulation comprising:
- 1.2 wt. % clindamycin phosphate;
- 3.1 wt. % benzoyl peroxide comprising a plurality of benzoyl peroxide particles;
- 0.15 wt. % adapalene comprising a plurality of adapalene particles;
- a polyhydric alcohol selected from the group consisting of propylene glycol, ethoxydiglycol, glycerol, and combinations thereof;
- a gelling agent selected from the group consisting of hydroxypropylcellulose, hydroxyethylcellulose, carboxyvinyl polymers, carboxyvinyl copolymers, polyacrylates, acrylate copolymers, acrylamide/sodium acryloyldimethyltaurate copolymers, methylcellulose, hydroxypropylmethylcellulose, xanthan gum, carrageenan gum, and combinations thereof;
- and
- potassium hydroxide,
- wherein the plurality of benzoyl peroxide particles and the plurality of adapalene particles are uniformly dispersed in the formulation.
5 more elements
Dependencies are inferred from the claim text.