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US 12,616,678 B2Granted
Methods to of aldehyde dehydrogenases for treatment of cancer
AssigneeThe Penn State Research Foundation
InventorsGavin P. Robertson, Venkata Saketh Sriram Dinavahi, Raghavendra Gowda Chandagalu Doreswamy, Todd Schell, Kishore Punnath
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Abstract
Disclosed are compositions and methods for inhibiting aldehyde dehydrogenases. In further aspects, treatment of cancers by inhibiting aldehyde dehydrogenases with the disclosed compositions are also disclosed.
Claims30
A method of treating cancer in a subject, comprising:
- administering a therapeutically effective amount of a checkpoint inhibitor or a BRAF inhibitor and a composition comprising a compound of Formula I
- wherein,
- X is S or Se;
- L is a C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C6 cycloalkyl, C5-C6 heterocycloalkyl, or phenyl, any of which is optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, NH2, CO2H, CO2C1-C6 alkyl, halide, OH, or NO2;
- n is 0, 1, 2, or 3;
- R1 and R2 are each independently chosen from H, F, Cl, Br, I, NO2, OH, C1-C6 alkyl, C1-C6 alkoxyl, or C1-C6 haloalkyl,
- or a pharmaceutically acceptable salt thereof.
4 more elements
A composition comprising a checkpoint inhibitor or a BRAF inhibitor and a composition comprising a compound of Formula I
- wherein,
- X is S or Se;
- L is a C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C6 cycloalkyl, C5-C6 heterocycloalkyl, or phenyl, any of which is optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, NH2, CO2H, CO2C1-C6 alkyl, halide, OH, or NO2;
- n is 0, 1, 2, or 3;
- R1 and R2 are each independently chosen from H, F, Cl, Br, I, NO2, OH, C1-C6 alkyl, C1-C6 alkoxyl, or C1-C6 haloalkyl,
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.