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US 12,616,677 B2Granted
Injectable pharmaceutical compositions and uses thereof
AssigneeIntervet Inc.
InventorsBrenda L. Valle Colon, Keith A. Freehauf, Frank Guerino, Christopher D. Kulczar, Brian Carrillo
Life of this patent
Estimating the term…
Abstract
An injectable pharmaceutical composition comprising an isoxazoline compound of Formula (I), or a salt or N-oxide and moxidectin microspheres and a method of preventing or treating a parasite infestation using the same.
Claims19
An injectable veterinary composition comprising
- a) moxidectin microspheres comprising from about 50% to about 99% by weight of a fat, wax or mixture thereof, and 0.01-10% by weight of an anti-oxidant;
- and
- b) particles of an isoxazoline compound
- wherein the isoxazoline compound is fluralaner
- wherein the moxidectin microspheres and isoxazoline compound particles are suspended in an aqueous carrier comprising one or more suspending agents selected from sodium carboxymethylcellulose, polyvinylpyrrolidone and methylcellulose, one or more wetting agents comprising a poloxamer, and water and optionally one or more preservatives.
2 more elements
A kit, wherein the kit comprises:
- a) a first container comprising a solid mixture of particles of isoxazoline compound wherein the isoxazoline compound is fluralaner and moxidectin microspheres comprising from about 50% to about 99% by weight of a fat, wax or mixture thereof, and 0.01-10% by weight of an anti-oxidant and;
- b) a second container with an aqueous carrier comprising one or more suspending agents wherein the suspending agent is selected from sodium carboxymethylcellulose, polyvinylpyrrolidone and methylcellulose,
- one or more wetting agents comprising poloxamer, and water and optionally preservatives;
- and
- c) instructions for reconstituting moxidectin microspheres and isoxazoline compound particles with the aqueous carrier prior to subcutaneous or intramuscular injection to the animal.
2 more elements
Dependencies are inferred from the claim text.