Preparation method and use of modified hydrophobic excipient

A method for preparing a modified hydrophobic excipient, wherein the method comprises the following steps:

• Step A. subjecting castor oil and N-tert-butoxycarbonyl-glycine acting as raw material, a dehydrating agent and a catalyst to an esterification reaction to generate intermediate I:
• castor oil-O—(N-t-butoxycarbonylglycine) triester, and adding an organic acid into the intermediate I, or performing catalytic hydrogenation to remove an amino protecting group of N-tert-butyloxycarbonyl, so as to generate intermediate II:
• castor oil-O-glycine triester;
• a structural formula of intermediate I is as follows:
• a structural formula of intermediate II is as follows:
• Step B. subjecting N-fluorenylmethoxycarbonyl-N′-tert-butoxycarbonyl-L-lysine and N-hydroxysuccinimide acting as raw material and a dehydrating agent to an esterification reaction to obtain intermediate III:
• N-fluorenylmethoxycarbonyl-N′-tertbutylcarbonyl-L-lysine-N-hydroxysuccinimide ester;
• and
• Step C. reacting the intermediate II and the intermediate III as raw material with an acid-binding agent under a dark condition to generate a modified hydrophobic excipient, a structural formula of the modified hydrophobic excipient is as follows:
• wherein, the dehydrating agent is dicyclohexylcarbodiimide, the catalyst is 4-dimethylaminopyridine or pyridine, the acid-binding agent is triethylamine, and the organic acid is trifluoroacetic acid.