Plant-derived exosome-like nanoparticles inhibit bacterial pathogenicity
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorHuang-Ge Zhang
Life of this patent
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Abstract
Provided are methods for preventing and/or treating oral diseases, disorders, and/or conditions. In some embodiments, the methods relate to administering to the oral cavity of a subject in need thereof a composition that includes an effective amount of ginger-derived exosome-like nanoparticles (GELNs) or a biologically active component thereof. Also provided are methods for preventing and/or treating periodontitis, methods for reducing growth of and/or pathogenicity of microorganisms in the oral cavities of subjects, methods for reducing microorganismal motility, and methods for reducing bone loss in the oral cavities of subjects associated with infection with microorganisms. Also provided are compositions that can be employed in the disclosed methods.
Claims10
A method for inhibiting and/or treating periodontitis or oral disease associated with a Porphyromonas gingivalis (P. gingivalis) infection, the method comprising administering to the oral cavity of a subject in need thereof a composition comprising a ginger-derived exosome-like nanoparticles (GELNs) or a biologically active component thereof;
- wherein the GELN can be obtained in bands between the 8%/30% layer and the 30%/45% layer of a sucrose step gradient;
- and wherein the GELN or the biologically active component is provided in an amount that is therapeutically effective for the inhibition and/or treatment of periodontitis or oral disease associated with a P. gingivalis infection.
A method for reducing growth of Porphyromonas gingivalis (P. gingivalis) in the oral cavity of a subject, the method comprising administering to the oral cavity of the subject a composition comprising a ginger-derived exosome-like nanoparticles (GELNs) or a biologically active component thereof;
- wherein the GELN can be obtained in bands between the 8%/30% layer and the 30%/45% layer of a sucrose step gradient;
- and wherein the GELN or the biologically active component is provided in an amount that is therapeutically effective for the inhibition and/or treatment of periodontitis or oral disease associated with a P. gingivalis infection.
Dependencies are inferred from the claim text.