Composition for type II diabetics and for use in providing sustained energy release over time
AssigneeTeagasc, The Agriculture and Food Development Authority
InventorsSinead Bleiel, Robert Kent, Neil Gerard Docherty, Carel Wynand Le Roux
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Abstract
A composition for use in a method of providing sustained energy release over time in a subject is described. The composition comprises or consists of microparticles comprising high glycaemic index (GI) carbohydrate contained within a gastric-resistant, ileal-sensitive, GLP-1 stimulative, non-porous carrier configured for release of the high GI carbohydrate in the ileum, wherein the composition is administered orally to the subject.
Claims20
A method of regulating post-prandial blood sugar levels in a diabetic or pre-diabetic subject, the method comprising orally administering to the subject a composition comprising or consisting of microparticles comprising a high glycaemic index (GI) carbohydrate contained within a gastric-resistant, ileal-sensitive, non-porous carrier configured for release of the high GI carbohydrate in the distal ileum, in which the non-porous carrier comprises polymerised protein in an amount sufficient to inhibit degradation of the microparticles in the duodenum at least 48 minutes after oral administration, and in which the microparticles release the high GI carbohydrate in the distal ileum wherein the microparticles have two coats of polymerised denatured protein.
A method of normalising blood glucose homeostasis in a diabetic or pre-diabetic subject, the method comprising orally administering to the subject a composition comprising or consisting of microparticles comprising a high glycaemic index (GI) carbohydrate contained within a gastric-resistant, ileal-sensitive, non-porous carrier configured for release of the high GI carbohydrate in the distal ileum, in which the non-porous carrier comprises polymerised protein in an amount sufficient to inhibit degradation of the microparticles in the duodenum at least 48 minutes after oral administration, and in which the microparticles release the high GI carbohydrate in the distal ileum wherein the microparticles have two coats of polymerised denatured protein.
A method of increasing or stimulating a GLP-1 response in a subject having a metabolic disorder characterised by dysregulated insulin production, the method comprising orally administering to the subject a composition comprising or consisting of microparticles comprising high glycaemic index (GI) carbohydrate contained within a gastric-resistant, ileal-sensitive, non-porous carrier configured for release of the high GI carbohydrate in the distal ileum, in which the non-porous carrier comprises polymerised protein in an amount sufficient to inhibit degradation of the microparticles in the duodenum at least 48 minutes after oral administration, and in which the microparticles release the high GI carbohydrate in the distal ileum wherein the microparticles have two coats of polymerised denatured protein.
A method of providing sustained energy release over time in a healthy subject, the method comprising orally administering the composition to the subject, the composition comprising or consisting of microparticles comprising a high glycaemic index (GI) carbohydrate contained within a gastric-resistant, ileal-sensitive, non-porous carrier configured for release of the high GI carbohydrate in the distal ileum, in which the non-porous carrier comprises polymerised protein in an amount sufficient to inhibit degradation of the microparticles in the duodenum at least 48 minutes after oral administration, and in which the microparticles release the high GI carbohydrate in the distal ileum wherein the microparticles have two coats of polymerised denatured protein.
A method of regulating post-prandial blood sugar levels in a diabetic or pre-diabetic subject, the method comprising orally administering to the subject a composition comprising or consisting of microparticles comprising a high glycaemic index (GI) carbohydrate contained within a gastric-resistant, ileal-sensitive, non-porous carrier configured for release of the high GI carbohydrate in the distal ileum, in which the non-porous carrier comprises polymerised protein in an amount sufficient to inhibit degradation of the microparticles in the duodenum at least 48 minutes after oral administration, and in which the microparticles release the high GI carbohydrate in the distal ileum wherein the microparticles have two coats of polymerised denatured protein and wherein the microparticles are formed by a method comprising the steps of:
- providing solid carbohydrate microparticles on a fluidised bed;
- spraying a denatured protein solution onto the bed to coat the carbohydrate particles and form microparticles;
- and
- drying the microparticles,
- wherein a second denatured protein solution is sprayed on to the dried microparticles.
Dependencies are inferred from the claim text.