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US 12,616,576 B2Granted
Methods of modifying the porous surface of implants
AssigneeBiomet Manufacturing, LLC
InventorsDevendra Gorhe, Donald L. Yakimicki, Philip McBride
Life of this patent
Estimating the term…
Abstract
Methods are provided for modifying a porous surface of an implantable medical device by subjecting the porous surface to a modified micro-arc oxidation process to improve the ability of the medical device to resist microbial growth, to improve the ability of the medical device to adsorb a bioactive agent or a therapeutic agent, and to improve tissue in-growth and tissue on-growth of the implantable medical device.
Claims21
A method of manufacturing a medical device, comprising:
- securing an electrode to a metallic substrate in an electrolyte solution, wherein the metallic substrate includes a porous layer and a non-porous layer, wherein the porous layer is configured to facilitate tissue in-growth or tissue on-growth;
- providing a cathode in the electrolyte solution;
- applying a voltage to the metallic substrate to form a plurality of micro-pores on the porous layer by micro-arc oxidation;
- and
- simultaneously depositing a therapeutic agent on the non-porous layer and on the porous layer of the metallic substrate in the plurality of micro-pores;
- wherein depositing the therapeutic agent comprises electrophoretic deposition or electrodeposition of the therapeutic agent.
3 more elements
A method of manufacturing a medical device, comprising:
- securing an electrode to a metallic substrate in an electrolyte solution, wherein the metallic substrate includes a porous layer and a non-porous layer, wherein the porous layer is configured to facilitate tissue in-growth or tissue on-growth;
- providing a cathode in the electrolyte solution;
- applying a voltage to the metallic substrate to form a plurality of micro-pores on the porous layer by micro-arc oxidation;
- and
- depositing a therapeutic agent on the non-porous layer and on the porous layer of the metallic substrate in the plurality of micro-pores;
- wherein depositing the therapeutic agent comprises electrophoretic deposition or electrodeposition of the therapeutic agent and
- wherein depositing the therapeutic agent includes performing a second depositing process to deposit the therapeutic agent on the non-porous layer.
4 more elements
A method of manufacturing a medical device, comprising:
- securing an electrode to a metallic substrate in an electrolyte solution, wherein the metallic substrate includes a porous layer and a non-porous layer;
- providing a cathode in the electrolyte solution;
- and
- applying a voltage to the metallic substrate to form a plurality of micro-pores on a porous layer of the metallic substrate by micro-arc oxidation, wherein the porous layer is configured to facilitate tissue in-growth or tissue on-growth;
- circulating the electrolyte solution through a temperature regulating device to maintain a temperature of the electrolyte solution within a desired temperature range while applying the voltage;
- depositing a therapeutic agent on the plurality of micro-pores on the metallic substrate;
- and
- manipulating the voltage to the cathode or manipulating a current to control depositing of the therapeutic agent;
- wherein manipulating the voltage to the cathode or manipulating the current to control depositing of the therapeutic agent includes controlling the depositing to achieve a desired amount or concentration of the therapeutic agent absorbed by the porous layer and by the non-porous layer.
6 more elements
Dependencies are inferred from the claim text.