Optical spectroscopy and treatment planning software for photodynamic therapy of hollow cavities
AssigneeUniversity of Rochester
InventorTimothy M. Baran
Life of this patent
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Abstract
The present invention provides an optical probe system that allows for determination of optical properties at the wall of a hollow cavity and photosensitizer uptake at the time of photodynamic therapy (PDT). In one embodiment, this system provides for rigorous treatment planning to maximize efficacy and minimize risk to patients by optimizing the concentration of the scattering emulsion infused into the cavity and the delivered laser power.
Claims7
A method of delivering, detecting, and analyzing diffuse optical reflectance and fluorescence in a target tissue comprising the steps of:
- providing an optical probe system comprising at least one transmitting fiber having a proximal end and a distal end, at least one receiving fiber having a proximal end and a distal end, at least one light source, a spectrometer, and a controller;
- positioning the proximal end of the at least one transmitting fiber and the proximal end of the at least one receiving fiber at a surface of a target tissue;
- enabling and selecting the at least one light source for fluorescence or reflectance measurements;
- detecting a first spectra for the at least one receiving fiber by the spectrometer;
- detecting a second spectra without the at least one light source enabled to correct for dark background;
- correcting the first spectra for at least one of:
- dark background, system throughput and wavelength-dependent system response;
- analyzing the corrected first spectra by the controller to obtain optical property spectra for both absorption and scattering;
- performing an initial simulation of light propagation at a set scattering emulsion concentration and optical power;
- and
- determining the scattering emulsion concentration at which minimum laser power is required to achieve the fluence rate target in 95% of the target tissue;
- and
- treating a subject using the determined scattering emulsion concentration and laser power.
A method of analyzing diffuse optical reflectance and fluorescence in a target tissue and treating a subject comprising the steps of:
- delivering light to a surface of a target tissue and detecting a first spectra at the surface of the target tissue;
- detecting a control spectra at the surface of the target tissue in the absence of delivering light to the target tissue;
- correcting the first spectra based in part on the control spectra for at least one of:
- dark background, system throughput, and wavelength-dependent system response;
- determining one or more optical properties of the target tissue based on the first spectra;
- performing a simulation of light propagation in the target tissue at a set scattering emulsion concentration and optical power;
- determining a scattering emulsion at which a minimum laser power is required to achieve a fluence rate target in 95% of the target tissue;
- and
- treating a subject using the determined scattering emulsion concentration and laser power.
Dependencies are inferred from the claim text.