Systems and methods for image segmentation

A method for image segmentation, comprising:

• obtaining a target image to be segmented;
• obtaining a template image relating to the target image, the template image corresponding to an initial mask that reflects initial segmentations of the template image;
• determining a first transformation and an intermediate template image by preliminarily registering the template image to the target image;
• generating an intermediate mask based on the initial mask and the first transformation;
• determining, based on the intermediate mask, one or more first regions from the target image and one or more second regions from the intermediate template image, the one or more second regions corresponding to the one or more first regions respectively;
• determining a second transformation by registering each of the one or more second regions to the corresponding first region;
• and
• determining a target mask according to which the target image can be segmented based on one or more second transformations corresponding to the one or more second regions respectively and the intermediate mask.

A system, comprising:

• a storage device storing a set of instructions;
• at least one processor in communication with the storage device, wherein when executing the set of instructions, the at least one processor is configured to direct the system to perform operations including:
• obtaining a plurality of sample images each of which corresponds to an initial sample mask that reflects sample segmentations of the sample image;
• for each of the plurality of sample images, determining a registered sample image by registering the sample image to a reference image according to at least one transformation;
• and
• determining a template image based on the plurality of registered sample images, including:
• determining the template image by performing an averaging operation on the plurality of registered sample images;
• for each of the plurality of sample images, determining a registered sample mask based on the initial sample mask corresponding to the sample image and the at least one transformation, the registered sample mask reflecting registered sample segmentations corresponding to the sample segmentations;
• for each pixel in the template image, determining probabilities of the pixel belonging to the registered sample segmentations;
• and
• determining an initial probability graph and an initial mask corresponding to the template image based on the probabilities corresponding to the pixels in the template image, the initial mask reflecting initial segmentations of the template image.