Large language model interface for complex databases

A system for querying a database comprising:

• a processor;
• a memory;
• an interface configured to receive a natural language query containing a reference to a biological sequence and display an answer received from a large language model (LLM), the answer containing the biological sequence;
• a custom prompt generator configured to generate a custom prompt from the natural language query containing the reference to the biological sequence and provide the custom prompt to the LLM, wherein the custom prompt includes instructions to access a database look-up tool;
• and
• the database look-up tool configured to submit queries and obtain data from the database, the database look-up tool comprising:
• a first tool that is configured to query the database with the reference to the biological sequence and receive a database-specific gene identifier;
• and
• a second tool that is configured to query the database with the database-specific gene identifier and retrieve a sequence identifier.

Computer-readable storage media comprising instructions that, when executed by a computing device, cause the computing device to perform actions comprising:

• receiving a natural language query containing a reference to a biological sequence;
• generating a custom prompt from the natural language query that includes instructions to access a database look-up tool;
• providing the custom prompt to a large language model (LLM);
• extracting, by the LLM, the reference to the biological sequence and the instructions to access the database look-up tool;
• retrieving the biological sequence from a database by the database look-up tool under control of the LLM, wherein the database look-up tool comprises three tools chained together and retrieving the biological sequence further comprises:
• querying, by a first tool, the database with the reference to the biological sequence and retrieving a database-specific gene identifier;
• querying, by a second tool, the database with the database-specific gene identifier and retrieving a sequence identifier;
• and
• querying, by a third tool, the database with the sequence identifier and retrieving the biological sequence;
• and
• generating an answer containing the biological sequence.