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US 12,613,246 B2Granted
Fluorescent probe and protein labeling method
AssigneeFluorescence Diagnosis (Shanghai) Biotech Company
InventorsLinyong Zhu, Yi Yang, Bingkun Bao, Ni Su, Dasheng Zhang, Xianjun Chen, Qiuning Lin, Chunyan Bao
Life of this patent
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Abstract
Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe sensitively and specifically responds to viscosity, and can be used for the specific fluorescence labeling of proteins as well as in the quantification, detection or kinetic study of proteins and the imaging of cells, tissues and living bodies.
Claims11
A fluorescent probe
- having a structure represented by formula (I):
- wherein:
- the A is selected from the following structures:
- the C is —(C═O)—O—CH2—;
- the D is
- X1 is selected from hydrogen and a C1-C30 linear or branched alkyl, X2 is a C1-C30 linear or branched alkylene;
- the B has any one of structures represented by formula (I-1-1) to (I-1-2) and formula (I-1-4) to (I-1-7):
- a structural part of formula (I) as shown in formula (I-2) has any one of the following formula (I-2-1) to (I-2-11), (I-2-13), (I-2-15) and (I-2-18):
5 more elements
Dependencies are inferred from the claim text.