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AssigneePivot Bio, Inc.
InventorsSarah Bloch, Karsten Temme, Alvin Tamsir, Douglas Higgins, Austin Davis-Richardson, Rosemary Clark, Shayin Gottlieb
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The present disclosure provides guided microbial remodeling (GMR) methods for the rational improvement of plant-associated microbes to perform plant-beneficial functions. The GMR methods described herein allow for non-intergeneric genetic optimization of key regulatory networks within the microbes, which improve plant-beneficial functions over wild-type microbes but don't have the risks associated with transgenic approaches (e.g., unpredictable gene function, public and regulatory concerns, etc.). The present disclosure also provides remodeled microbes and compositions thereof. The utilization of remodeled microbes and compositions thereof will enable farmers to realize more productive and predictable crop yields without the nutrient degradation, leaching, or toxic runoff associated with traditional synthetically derived fertilizers.
A guided microbial remodeling method for the rational improvement of the fitness of genetically modified plant-associated microbes, comprising:
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