BCMA-binding single variable structural domain and antigen-binding molecule
AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.
InventorsZipeng Zhen, Meijuan Xie, Xiuzhen Du, Yimin Ma, Bing Zhang, Tongjie Xu, Xiquan Zhang
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Abstract
A BCMA-binding immunoglobulin single variable structural domain and an antigen-binding molecule including an immunoglobulin single variable structural domain and an antigen-binding molecule, a nucleic acid encoding the above, a vector containing the nucleic acid, a cell containing the vector, and a pharmaceutical composition containing the above, as well as a therapeutic use thereof.
Claims16
An isolated single variable domain that binds to BCMA, wherein the single variable domain comprises CDR1, CDR2 and CDR3 selected from any one of the following:
- (i) CDR1 comprising an amino acid sequence of SEQ ID NO:
- 7;
- CDR2 comprising an amino acid sequence of SEQ ID NO:
- 8;
- and CDR3 comprising an amino acid sequence of SEQ ID NO:
- 9;
- (ii) CDR1 comprising an amino acid sequence of SEQ ID NO:
- 10;
- CDR2 comprising an amino acid sequence of SEQ ID NO:
- 11;
- and CDR3 comprising an amino acid sequence of SEQ ID NO:
- 12;
- and
- (iii) CDR1 comprising an amino acid sequence of SEQ ID NO:
- 13;
- CDR2 comprising an amino acid sequence of SEQ ID NO:
- 14;
- and CDR3 comprising an amino acid sequence of SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.