Small RNA medicament for prevention and treatment of inflammation-related diseases and combination thereof
AssigneeBeijing Baishihekang Pharmaceutical Technology (Bsjpharma) Co., Ltd
InventorsChengyu Jiang, Dandan Zhao, Yuhao Qin, Cong Zhang, Yexuan Lin
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Abstract
Provided is a small RNA, a composition comprising the small RNA, a method for using same and use of same. The small RNA or composition can inhibit the ability of any one or more of pathways or genes listed in Table 3, or decrease or down regulate the expression level of IL-1 beta, IL-6, and/or TNF-alpha in vitro or in vivo, or treat or prevent IL-1 beta, IL-6, and/or TNF-alpha related diseases and/or increase cell viability in a subject.
Claims15
A method for reducing or down-regulating the expression level of IL-1 beta, IL-6 or/and TNF-alpha in vitro or in vivo, comprising administering to a cell or a subject having inflammation at least one of:
- (a) a single-stranded small RNA consisting of SEQ ID NO:
- 20 or a double-stranded small RNA, wherein one strand consists of SEQ ID NO:
- 20 and the other strand consists of the complement thereof,
- (b) a construct comprising a sequence encoding the small RNA,
- (c) a recombinant virus comprising the construct of (b),
- (d) an expression vector comprising a sequence encoding the small RNA,
- (c) a cell comprising the construct of (b);
- and
- (f) a pharmaceutical composition comprising the (a), (b), (c), (d), or (e).
A method for improving cell survival rate in an H5N1 virus infection, comprising administering to a cell or a subject infected with the H5N1 virus at least one of:
- (a) a single-stranded small RNA consisting of SEQ ID NO:
- 20 or a double-stranded small RNA wherein one strand consists of SEQ ID NO:
- 20 and the other strand consists of the complement thereof,
- (b) a construct comprising a sequence encoding the small RNA,
- (c) a recombinant virus comprising the construct of (b),
- (d) an expression vector comprising a sequence encoding the small RNA,
- (e) a cell comprising the construct of (b);
- and
- (f) a pharmaceutical composition comprising the (a), (b), (c), (d) or (e).
Dependencies are inferred from the claim text.