siRNA compound that inhibits expression of APOC3
AssigneeSirnaomics, Inc.
InventorDmitry Samarsky
Life of this patent
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Abstract
Nucleic acid products and compositions and their uses are provided. In particular, nucleic acid products are provided that modulate, interfere with, or inhibit APOC3 gene expression. The products can be oligomeric compounds that comprise at least a first region of linked nucleosides having at least a first nucleobase sequence that is at least partially complementary to at least a portion of RNA transcribed from a APOC3 gene, wherein said first nucleobase sequence is selected from the following sequences, or a portion thereof: SEQ ID NOs 1 to 39
Claims18
An siRNA compound that inhibits expression of APOC3, comprising a single strand of 33 or 34 nucleobases that is modified or unmodified, wherein said single strand comprises:
- (i) a first nucleobase sequence directly linked to
- (ii) a second nucleobase sequence,
- wherein said first and second nucleobase sequences form a hairpin loop consisting of a duplex region of 14 or 15 base pairs, and a loop consisting of 4 or 5 nucleosides, wherein said first and second nucleobase sequences in unmodified form are, respectively, SEQ ID NOs:
- 23 and 423;
- 24 and 424;
- 28 and 428;
- 29 and 429;
- 31 and 431;
- 89 and 489;
- 90 and 490;
- 94 and 494;
- 117 and 517;
- 121 and 521;
- 128 and 528;
- 137 and 537;
- 138 and 538;
- 148 and 548;
- 149 and 549;
- 167 and 567;
- 171 and 571;
- 175 and 575;
- 185 and 585;
- 191 and 591;
- 193 and 593;
- 206 and 606;
- 209 and 609;
- 212 and 612;
- 213 and 613;
- 217 and 617;
- 218 and 618;
- 219 and 619;
- 220 and 620;
- 221 and 621;
- 223 and 623;
- 225 and 625;
- 254 and 654;
- 262 and 662;
- 271 and 671;
- 272 and 672;
- 274 and 674;
- 275 and 675;
- 276 and 676;
- 277 and 677;
- 278 and 678;
- 280 and 680;
- 281 and 681;
- 282 and 682;
- 283 and 683;
- 285 and 685;
- 286 and 686;
- 291 and 691;
- 293 and 693;
- 296 and 696;
- 297 and 697;
- 299 and 699;
- 300 and 700;
- 303 and 703;
- 324 and 724;
- 328 and 728;
- 331 and 731;
- 332 and 732;
- 334 and 734;
- 336 and 736;
- 337 and 737;
- 338 and 738;
- 339 and 739;
- 340 and 740;
- 341 and 741;
- 342 and 742;
- 343 and 743;
- 345 and 745;
- 346 and 746;
- 347 and 747;
- 366 and 766;
- 367 and 767;
- 369 and 769;
- 370 and 770;
- 368 and 768;
- 372 and 772;
- 373 and 773.
An siRNA compound that inhibits expression of APOC3, comprising a single strand that is modified or unmodified, wherein the nucleobase sequence of said single strand consists of, in unmodified form, a nucleobase sequence selected from the group consisting of SEQ ID NOs:
- 796-798, and 801-803 and wherein the nucleobase sequence of said single strand consists of, in modified form, a nucleobase sequence selected from the group consisting of SEQ ID NOs:
- 1590-1592 and SEQ ID NOs:
- 1595-1597.
Dependencies are inferred from the claim text.