Back to results
US 12,612,610 B2Granted
Compositions and methods for controlling blood pressure
AssigneeDuke University
InventorsConrad P. Hodgkinson, Hualing Sun, Richard Pratt, Victor J. Dzau
Life of this patent
Estimating the term…
Abstract
The present disclosure describes compositions and methods for treating hypertension in a subject.
Claims18
A guide RNA (gRNA) that targets an angiotensinogen (AGT) gene and comprising the polynucleotide sequence of guide RNA to target human AGT gene comprises CCTTCCACCTCGTCATCCACA (human gRNA1;
- SEQ ID NO:
- 1);
- TCATTGTGGATGACGAGGTGG (human gRNA2;
- SEQ ID NO:2), or GATATTTCAGGGTATGCGGAA (human gRNA3;
- SEQ ID NO:3).
2 more elements
A method of treating a subject suffering from hypertension or prehypertension, comprising administering to the subject a composition comprising;
- (i) a guide RNA (gRNA) that targets an angiotensinogen (AGT) gene, said gRNA comprising the polynucleotide sequence of CCTTCCACCTCGTCATCCACA (human gRNA1;
- SEQ ID NO:1);
- TCATTGTGGATGACGAGGTGG (human gRNA2;
- SEQ ID NO:2), or GATATTTCAGGGTATGCGGAA (human gRNA3;
- SEQ ID NO:3);
- (ii) a hepatocyte-tropic vector;
- and (iii) a CRISPR/Cas system comprising a Cas9 nuclease.
4 more elements
Dependencies are inferred from the claim text.