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US 12,612,602 B2Granted
Production of a bioengineered lung
AssigneeBoard of Regents, The University of Texas System
InventorsJoaquin Cortiella, Joan E. Nichols, Jean Niles, Saverio Lafrancesca, Jason Sakamoto
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Abstract
The present invention provides processes for producing a bioengineered lung (BEL) from an acellular lung matrix that has been treated with growth hormones, seeded with primary lung cells, and cultured in a bioreactor. Also provided are BELs and methods of transplanting the BEL into a subject in need of a lung transplant, and methods for using BELs for the study of the lung microbiome and its role in lung development and remodeling.
Claims20
A method for producing a bioengineered lung (BEL) comprising:
- (a) obtaining an acellular (AC) lung scaffold from lungs perfused with a dextrose solution prior to decellularization;
- (b) treating the AC lung scaffold with one or more growth factors, wherein the growth factors are delivered by porous nanoparticles or porous microparticles;
- (c) seeding the treated AC lung scaffold with primary lung cells;
- and
- (d) culturing the seeded AC lung scaffold in a bioreactor to produce a functional BEL.
2 more elements
Dependencies are inferred from the claim text.