Electroceutical screening device and screening method using same
AssigneeDaegu Gyeongbuk Institute of Science and Technology
InventorsMin Seok Kim, Hyun Gyu Kang, Woon Hae Kim
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Abstract
The present invention relates to an electroceutical screening device and a screening method using same, respectively, wherein an electrical stimulation is applied, through the electrodes, to the cell clusters received in the channels, and the potentials of the cell clusters are measured so as to measure neural activity, and thus electrical stimulation tests are conducted in various ways, and by measuring conduction velocity according to the various electrical stimulation tests, conditions for electrical stimulation therapy are assessed.
Claims11
An electroceutical screening device, comprising:
- a microfluidic chip including a cell culture part which is a space for receiving cell bodies, and a microchannel assembly which is connected to the cell culture part so that cell clusters, which are at least a portion of the cell bodies, grow as time passes, and which includes multiple channels, for receiving the cell clusters, formed around the cell culture part;
- and
- a substrate which is coupled to the microfluidic chip and includes an electrode assembly including electrodes provided in positions each corresponding to the cell culture part and the multiple channels, respectively,
- wherein one end of a first electrode, which is at least one of the electrodes, is formed at a lower position corresponding to the cell culture part, and electrical stimulation is applied to the cell body received in the cell culture part through the first electrode,
- wherein one end of each of n second electrodes, where n is a natural number, is formed at a position corresponding to the channel and connected to one side of the cell clusters,
- wherein one end of each of m third electrodes, where m is a natural number, is formed at a position corresponding to the channel, connected to the other side of the cell clusters, and located on the inner side closer to the cell culture part than the second electrodes, and
- wherein electrical stimulation tests are performed by receiving the electrical stimulus applied through the first electrode by the second electrodes via the third electrodes.
Dependencies are inferred from the claim text.