Back to results
US 12,612,509 B2Granted
Biocompatible membrane, preparation method therefor, and implantable biosensor
AssigneeSinocare Inc.
InventorZhiqiang Gao
Life of this patent
Estimating the term…
Abstract
A biocompatible membrane including a crosslinking agent, a hydrophilic material, a hydrophobic material, and a solvent; the biocompatible membrane can implement simultaneous regulation of oxygen and glucose, thereby improving the stability and service life of a biocompatible membrane solution, a preparation method for the biocompatible membrane and an implantable biosensor.
Claims7
A biocompatible membrane, comprising:
- a crosslinking agent,
- a hydrophilic material,
- a hydrophobic material, and
- a solvent, wherein the crosslinking agent comprises one or more materials selected from poly (dimethylsiloxane)-diglycidyl ether, polyethylene glycol diglycidyl ether, and 4-(2,3-epoxy propoxy)-N, N-(2,3-epoxy propyl) diphenylamine, wherein the hydrophilic material comprises one or more materials selected from polyethylene oxide, copolymer containing polyethylene oxide, propylene oxide, copolymer containing propylene oxide, polyvinylpyrrolidone, and polyvinyl alcohol, wherein the hydrophobic material comprises one or more materials selected from polyvinyl pyridine, vinyl pyridine-acrylamide copolymer, polyvinyl pyrrole, and vinyl pyrrole-acrylamide copolymer;
- wherein raw materials of the biocompatible membrane further comprise a free radical scavenger, wherein the free radical scavenger comprises one or more materials selected from ethanolamine, propanolamine, isopropanolamine, aniline, polyethylene oxide with terminal amino groups, ethylene oxide copolymer, and polypropylene oxide with terminal amino groups.
2 more elements
A preparation method for a biocompatible membrane, comprising the steps of:
- Step A:
- mixing a crosslinking agent, a hydrophilic material and a hydrophobic material in a solvent, letting them react for 40-120 minutes at a temperature of 20-70° C., and then letting them react for 40-120 minutes at a temperature of 40-70° C., thereby obtaining a biocompatible membrane solution, wherein the crosslinking agent comprises one or more materials selected from poly (dimethylsiloxane)-diglycidyl ether, polyethylene glycol diglycidyl ether, and 4-(2,3-epoxy propoxy)-N, N-(2,3-epoxy propyl) diphenylamine, wherein the hydrophilic material comprises one or more materials selected from polyethylene oxide, a copolymer containing polyethylene oxide, propylene oxide, a copolymer containing propylene oxide, polyvinylpyrrolidone, and polyvinyl alcohol, wherein the hydrophobic material comprises one or more materials selected from polyvinyl pyridine, vinyl pyridine-acrylamide copolymer, polyvinyl pyrrole, and vinyl pyrrole-acrylamide copolymer;
- Step B:
- immersing a base body in the biocompatible membrane solution and coating the biocompatible membrane solution on a surface of the base body by using a dip-coating method;
- Step C:
- drying the base body coated with the biocompatible membrane solution, thereby obtaining a base body covered by the biocompatible membrane.
3 more elements
Dependencies are inferred from the claim text.