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US 12,612,467 B2Granted
Treatment of necrotizing enterocolitis with semisynthetic polyclonal human secretory immunoglobin A
OwnerMichael R. Simoninventor
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Abstract
A process is provided for inhibiting or preventing symptoms of necrotizing enterocolitis in a subject that includes the oral administration to the subject of a human polyclonal secretory IgA formed by the conjugation of human recombinant secretory component and pooled human plasma derived dimeric and polymeric. When administered in a therapeutic quantity, symptoms of necrotizing enterocolitis in the subject are inhibited or precluded.
Claims5
A process for treatment of necrotizing enterocolitis in a premature infant subject suffering therefrom, the process comprising:
- purifying IgA from healthy human plasma;
- modifying said IgA with recombinant human secretory component to form a purified mixture having only therapeutic effective components selected from the group consisting of dimeric secretory IgA, polymeric secretory IgA, and a combination thereof;
- administering orally to the premature infant subject suffering from necrotizing enterocolitis said purified mixture;
- and
- allowing sufficient time for said purified mixture to treat the necrotizing enterocolitis in the premature infant subject.
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Dependencies are inferred from the claim text.