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US 12,612,455 B2Granted
Feline antibody variants
AssigneeZoetis Services LLC
InventorsLisa Marie Bergeron, Henry Luis Campos
Life of this patent
Estimating the term…
Abstract
The invention relates generally to feline antibody variants and uses thereof. Specifically, the invention relates to mutations in the constant region of feline antibody for improving its half-life and other characters.
Claims15
A modified IgG comprising:
- a feline IgG constant domain comprising at least one amino acid substitution relative to a wild-type feline IgG constant domain, wherein said substitution is at amino acid residue 434, numbered according to the EU index as in Kabat,
- wherein said substitution is a substitution of serine at position 434 with histidine (S434H),
- wherein said IgG is an anti-TGFβ molecule, and
- wherein the anti-TGFβ molecule comprises a variable heavy (VH) chain having the amino acid sequence set forth in SEQ ID NO.:
- 45, 55, 65, 75, 85, 95, 105, 115, 125, or 135 and a variable light (VL) chain having the amino acid sequence set forth in SEQ ID NO.:
- 47, 57, 67, 77, 87, 97, 107, 117, 127, or 137.
3 more elements
A method for increasing the serum half-life of a feline IgG molecule in a cat, the method comprising:
- administering said cat a composition comprising a modified IgG, said modified IgG comprising a feline IgG constant domain, said feline IgG constant domain comprising at least one amino acid substitution relative to a wild-type feline IgG constant domain, wherein said substitution is at amino acid residue 434, numbered according to the EU index as in Kabat, wherein said substitution is a substitution of serine at position 434 with histidine (S434H), wherein said IgG is an anti-TGFβ molecule, and wherein the anti-TGFβ molecule comprises a variable heavy (VH) chain having the amino acid sequence set forth in SEQ ID NO.:
- 45, 55, 65, 75, 85, 95, 105, 115, 125, or 135 and a variable light (VL) chain having the amino acid sequence set forth in SEQ ID NO.:
- 47, 57, 67, 77, 87, 97, 107, 117, 127, or 137.
Dependencies are inferred from the claim text.