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US 12,612,449 B2Granted
HIV-1 antibodies
AssigneeThe University of Melbourne
InventorsDamian Purcell, Behnaz Heydarchi
Life of this patent
Estimating the term…
Abstract
The invention relates to antigen binding sites, antibodies and fragments thereof, as well as compositions, kits and uses thereof for the treatment, attenuation and/or prevention of human immunodeficiency virus type 1 (HIV-1).
Claims10
An antibody or antigen binding fragment thereof for binding human immunodeficiency virus type 1 (HIV-1), wherein the antibody or antigen binding fragment thereof comprises:
- a) a heavy chain complementarity determining region 1 (CDRH1) set forth in SEQ ID NO:
- 1, a CDRH2 set forth in SEQ ID NO:
- 2, a CDRH3 set forth in SEQ ID NO:
- 3, a light chain complementarity determining region 1 (CDRL1) set forth in SEQ ID NO:
- 39, a CDRL2 set forth in SEQ ID NO:
- 40, and a CDRL3 set forth in SEQ ID NO:
- 41;
- b) a CDRH1 set forth in SEQ ID NO:
- 1, a CDRH2 set forth in SEQ ID NO:
- 2, a CDRH3 set forth in SEQ ID NO:
- 3, a CDRL1 set forth in SEQ ID NO:
- 74, a CDRL2 set forth in SEQ ID NO:
- 75, and a CDRL3 set forth in SEQ ID NO:
- 76;
- c) a CDRH1 set forth in SEQ ID NO:
- 1, a CDRH2 set forth in SEQ ID NO:
- 2, a CDRH3 set forth in SEQ ID NO:
- 3, a CDRL1 set forth in SEQ ID NO:
- 83, a CDRL2 set forth in SEQ ID NO:
- 84, and a CDRL3 set forth in SEQ ID NO:
- 85;
- d) a CDRH1 set forth in SEQ ID NO:
- 87, a CDRH2 set forth in SEQ ID NO:
- 88, a CDRH3 set forth in SEQ ID NO:
- 89, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 133;
- e) a CDRH1 set forth in SEQ ID NO:
- 87, a CDRH2 set forth in SEQ ID NO:
- 88, a CDRH3 set forth in SEQ ID NO:
- 89, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 76;
- f) a CDRH1 set forth in SEQ ID NO:
- 87, a CDRH2 set forth in SEQ ID NO:
- 88, a CDRH3 set forth in SEQ ID NO:
- 89, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 85;
- g) a CDRH1 set forth in SEQ ID NO:
- 17, a CDRH2 set forth in SEQ ID NO:
- 18, a CDRH3 set forth in SEQ ID NO:
- 19, a CDRL1 set forth in SEQ ID NO:
- 39, a CDRL2 set forth in SEQ ID NO:
- 40, and a CDRL3 set forth in SEQ ID NO:
- 41;
- h) a CDRH1 set forth in SEQ ID NO:
- 17, a CDRH2 set forth in SEQ ID NO:
- 18, a CDRH3 set forth in SEQ ID NO:
- 19, a CDRL1 set forth in SEQ ID NO:
- 74, a CDRL2 set forth in SEQ ID NO:
- 75, and a CDRL3 set forth in SEQ ID NO:
- 76;
- i) a CDRH1 set forth in SEQ ID NO:
- 17, a CDRH2 set forth in SEQ ID NO:
- 18, a CDRH3 set forth in SEQ ID NO:
- 19, a CDRL1 set forth in SEQ ID NO:
- 83, a CDRL2 set forth in SEQ ID NO:
- 84, and a CDRL3 set forth in SEQ ID NO:
- 85;
- j) a CDRH1 set forth in SEQ ID NO:
- 101, a CDRH2 set forth in SEQ ID NO:
- 102, a CDRH3 set forth in SEQ ID NO:
- 103, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 133;
- k) a CDRH1 set forth in SEQ ID NO:
- 101, a CDRH2 set forth in SEQ ID NO:
- 102, a CDRH3 set forth in SEQ ID NO:
- 103, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 76;
- l) a CDRH1 set forth in SEQ ID NO:
- 101, a CDRH2 set forth in SEQ ID NO:
- 102, a CDRH3 set forth in SEQ ID NO:
- 103, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 85;
- m) a CDRH1 set forth in SEQ ID NO:
- 33, a CDRH2 set forth in SEQ ID NO:
- 34, a CDRH3 set forth in SEQ ID NO:
- 35, a CDRL1 set forth in SEQ ID NO:
- 39, a CDRL2 set forth in SEQ ID NO:
- 40, and a CDRL3 set forth in SEQ ID NO:
- 41;
- n) a CDRH1 set forth in SEQ ID NO:
- 33, a CDRH2 set forth in SEQ ID NO:
- 34, a CDRH3 set forth in SEQ ID NO:
- 35, a CDRL1 set forth in SEQ ID NO:
- 74, a CDRL2 set forth in SEQ ID NO:
- 75, and a CDRL3 set forth in SEQ ID NO:
- 76;
- o) a CDRH1 set forth in SEQ ID NO:
- 33, a CDRH2 set forth in SEQ ID NO:
- 34, a CDRH3 set forth in SEQ ID NO:
- 35, a CDRL1 set forth in SEQ ID NO:
- 83, a CDRL2 set forth in SEQ ID NO:
- 84, and a CDRL3 set forth in SEQ ID NO:
- 85;
- p) a CDRH1 set forth in SEQ ID NO:
- 115, a CDRH2 set forth in SEQ ID NO:
- 116, a CDRH3 set forth in SEQ ID NO:
- 117, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 133;
- q) a CDRH1 set forth in SEQ ID NO:
- 115, a CDRH2 set forth in SEQ ID NO:
- 116, a CDRH3 set forth in SEQ ID NO:
- 117, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 76;
- or
- r) a CDRH1 set forth in SEQ ID NO:
- 115, a CDRH2 set forth in SEQ ID NO:
- 116, a CDRH3 set forth in SEQ ID NO:
- 117, a CDRL1 set forth in SEQ ID NO:
- 131, a CDRL2 set forth in SEQ ID NO:
- 132, and a CDRL3 set forth in SEQ ID NO:
- 85.
124 more elements
Dependencies are inferred from the claim text.