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US 12,612,438 B2Granted
Bistable type II opsins and uses thereof
AssigneeYeda Research and Development Co. Ltd.
InventorsOfer Yizhar, Mathias Mahn
Life of this patent
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Abstract
Bistable type II opsins are provided. Accordingly, there is provided a polypeptide comprising a bistable type II opsin and a heterologous ER export signal and/or membrane trafficking signal. Also provided are polynucleotides encoding same, cells expressing same and methods of use thereof.
Claims5
A polynucleotide encoding a polypeptide comprising an OPN3 bistable type II opsin and ER export and membrane trafficking signals of a protein expressed in neuronal cells, said signals being heterologous to said OPN3 bistable type II opsin, wherein said ER export signal comprises SEQ ID NO:
- 2 and said membrane trafficking signal comprises SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.