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US 12,612,428 B2Granted
Process for solid-phase peptide synthesis and device
OwnerOliver Johannes Kreuzerinventor
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Abstract
A method for carrying out solid-phase peptide synthesis, to an automated parallel solid-phase peptide synthesis, and to a device designed to carry out such a method. Ultrasound with a frequency of more than 25 kHz acts at least intermittently during the method on the reaction medium in which the solid-phase peptide synthesis takes place.
Claims27
A method for carrying out solid-phase peptide synthesis comprising the steps of:
- a) binding an amino acid protected at the N-terminus by a protecting group to a solid support material via a C-terminus of the amino acid,
- b) splitting off the protecting group,
- c) performing at least one peptide propagation, and
- d) terminating the reaction by splitting off the peptide from the support material, wherein steps a) to d) take place in a liquid reaction medium, and at least during one of the steps, ultrasound with a frequency in the range of 25-100 to 2000 kHz acts at least intermittently on the reaction medium.
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Dependencies are inferred from the claim text.