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US 12,612,420 B2Granted
Arginase inhibitors and methods of use thereof
AssigneeMolecure S.A.
InventorsAnna Gzik, Jacek Chrzanowski, Bartlomiej Borek, Roman Blaszczyk, Jacek Olczak, Adam Golebiowski, Marcin Mikolaj Grzybowski, Paulina Pomper, Nazan Cemre Güner-Chalimoniuk, Kamil Lisiecki, Damian Kusmirek
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Abstract
The inventive compounds are small molecule therapeutics that are potent inhibitors of arginase 1 and arginase 2 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.
Claims10
A compound of the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- R8 is selected from the group consisting of D-alanyl, L-alanyl, L-arginyl, L-asparaginyl, glycyl, L-histidyl, L-isoleucyl, L-leucyl, L-tert-leucyl, L-lysyl, L-methionyl, L-norvalyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tryptophanyl, L-tyrosyl, D-valyl, L-valyl, (S)-2-amino-2-cyclopentylacetyl, (S)-2-amino-3-hydroxy-3-methylbutyryl, and (S)-2-amino-2,3-dimethylbutyryl;
- and
- R9 is hydrogen or methyl.
1 more element
Dependencies are inferred from the claim text.