Nitrile SUMO inhibitors and uses thereof

A compound of the structure of Formula IV or Formula V:

• wherein
• R1 is substituted or unsubstituted C2-C6 alkenyl, or substituted or unsubstituted C2-C6 alkynyl;
• R6 is selected from H, C1-6 alkyl, C2-4 alkynyl, C1-6 hydroxyalkyl, C1-6 alkoxyalkyl, C1-6 alkylamino-C1-6 alkyl, C1-6 alkylaminocarbonyl-C1-6 alkyl, aminocarbonyl-C1-6 alkyl, C1-6 alkoxycarbonyl-C1-6 alkyl, carboxy-C1-6 alkyl, C1-6 alkylcarbonylamino-C1-6 alkyl, C1-6 cyanoalkyl, C1-6 haloalkyl, C1-6 alkylsulfonyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-6 alkyl, aryl-C1-6 alkyl, substituted or unsubstituted 5 or 6 membered heteroaryl-C1-6 alkyl, substituted or unsubstituted 5 or 6 membered heterocyclyl and substituted or unsubstituted 5 or 6 membered heteroaryl;
• R7 is selected from H, carboxy, amino, C1-6 alkyl, C1-3 haloalkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 alkylaminocarbonyl, and C3-6 cycloalkyl;
• R8 is selected from H, carboxy, cyano, C1-4 alkyl, C1-3 haloalkyl, and C1-6 alkylaminocarbonyl;
• R9 is selected from H, halo, hydroxy, C1-3 alkyl, C1-3 haloalkyl, cyano, amino, C1-3 alkylcarbonylamino, C1-3 alkylsulfonylamino, and C1-3 alkylaminocarbonylamino;
• R10 is selected from H, halo, hydroxy, C1-3 alkyl, C1-3 haloalkyl, cyano, amino, C1-3 alkylcarbonylamino, C1-3 alkylsulfonylamino, and C1-3 alkylaminocarbonylamino;
• and
• R11 is selected from H, halo, hydroxy, C1-3 alkyl, C1-3 haloalkyl, cyano, amino, C1-3 alkylcarbonylamino, C1-3 alkylsulfonylamino, and C1-3 alkylaminocarbonylamino;
• or a pharmaceutically acceptable salt thereof.