Back to results
US 12,612,406 B2Granted
Cytisine salts
AssigneeAchieve Life Sciences, Inc.
InventorsAnthony Clarke, Richard Alistair Balfour Stewart
Life of this patent
Estimating the term…
Abstract
Salts of cytisine have been prepared and incorporated in stable pharmaceutical compositions, including compositions comprising lactose. The salts are prepared by adding acid stock solutions to solutions of cytisine with heating, followed by cooling to ambient temperature. The salts and compositions are indicated in the treatment of nicotine addiction.
Claims12
A gentisate salt of cytisine.
A method for making a gentisate salt of cytisine, the method comprising:
- (i) preparing a first solution, of an acid salt former, of gentisic acid;
- (ii) preparing a second solution, of cytisine;
- (iii) adding said first solution of the acid salt former to said second solution of cytisine;
- (iv) maintaining a solution obtained in step (iii) at an elevated temperature for a fixed period of time;
- (v) allowing the solution to cool to ambient temperature;
- (vi) filtering the cooled solution;
- and
- (vii) drying the obtained solids.
5 more elements
Dependencies are inferred from the claim text.