Nitrogen-containing heterocyclic derivative inhibitor, and preparation method therefor and use thereof
AssigneesShanghai Hansoh Biomedical Co., Ltd., Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
InventorsXinxian Deng, Jiaqiang Dong, Wensheng Yu, Fangfang Jin, Tingjun Wang
Life of this patent
Estimating the term…
Abstract
The present invention relates to a nitrogen-containing heterocyclic derivative inhibitor, and a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof as an inhibitor in the treatment of diseases such as cardiovascular diseases and cerebrovascular diseases, wherein the definition of each substituent in general formula (I) is the same as that defined in the description.
Claims26
A compound as represented by general formula (I-A), or a stereoisomer or pharmaceutically acceptable salt thereof:
- wherein
- ring A is selected from
- ring B is selected from
- Ra is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, oxo, thio, C1-6alkylthio, C1-6deuteroalkyl, C1-6haloalkyl, C1-6alkoxy, C1-6haloalkoxy, C1-6hydroxyalkyl, cyano-substituted C1-6alkyl, C3-8cycloalkyl or 3- to 8-membered heterocyclyl;
- Rb is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, C1-6 alkyl, C2-6alkenyl, C2-6alkynyl, oxo, thio, C1-6deuteroalkyl, C1-6haloalkyl, C1-6alkoxy, C1-6haloalkoxy, C1-6hydroxyalkyl, or cyano-substituted C1-6alkyl;
- Rc-1 is selected from halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 alkylthio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halo C1-3 alkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl or 3- to 8-membered heterocyclyl;
- Rc-2 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 alkylthio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halo C1-3 alkoxy, C1-3 hydroxyalkyl, or cyano-substituted C1-3 alkyl;
- Rc-3 is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-3 alkyl, C2-4 alkenyl, C2-4 alkynyl, oxo, thio, C1-3 alkylthio, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, halo C1-3 alkoxy, C1-3 hydroxyalkyl, cyano-substituted C1-3 alkyl, C3-8 cycloalkyl, or 3- to 8-membered heterocyclyl;
- Rd is selected from hydrogen, deuterium, halogen, amino, hydroxyl, cyano, nitro, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, oxo, thio, C1-6deuteroalkyl, C1-6haloalkyl, C1-6alkoxy, C1-6haloalkoxy, C1-6hydroxyalkyl, cyano-substituted C1-6alkyl, C3-8cycloalkyl, 3- to 8-membered heterocyclyl, C6-10 aryl, or C5-12heteroaryl;
- alternatively, any two adjacent or non-adjacent Rd are connected to form C3-8cycloalkyl or 3- to 8-membered heterocyclyl;
- x is 0, 1, 2, or 3;
- y is 0, 1, 2, or 3;
- and
- e is 0, 1, 2, or 3.
Dependencies are inferred from the claim text.