Pyrrolopyridine derivative preparation method
AssigneeSt Pharm Co., Ltd.
InventorsKyungjin Kim, Uk-Il Kim, Hyung Tae Bang
Life of this patent
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Abstract
The present invention relates to a method for preparing a pyrrolopyridine derivative compound exhibiting antiviral activity, and a novel intermediate used therein. The preparation method of the present invention enables reaction steps to be reduced through effective process development and a high purity pyrrolopyridine derivative compound to be prepared in a high yield, and thus enables production costs to be remarkably reduced so as to be economical and to be suitable for mass production.
Claims13
A method for preparing a compound represented by Chemical Formula I, the method comprising:
- (S-1) a first step of preparing a compound represented by the following Chemical Formula 3 by cyclization of a compound represented by the following Chemical Formula 1 or a salt thereof and a butanone derivative represented by the following Chemical Formula 2;
- (S-2) a second step of preparing a compound represented by the following Chemical Formula 4 by cyclization of the compound represented by Chemical Formula 3 and an acetopyruvate derivative;
- (S-3) a third step of preparing a compound represented by the following Chemical Formula 5 from the compound represented by Chemical Formula 4 by a chiral reduction;
- (S-4) a fourth step of preparing a compound represented by the following Chemical Formula 6 from the compound represented by Chemical Formula 5 by an alkylation;
- and
- (S-5) a fifth step of preparing a compound represented by the following Chemical Formula I from the compound represented by Chemical Formula 6 by a hydrolysis:
- in the Chemical Formulas above,
- X is Cl, Br or I, and
- R is C1-4alkyl.
A compound represented by the following Chemical Formula 3 or a salt thereof:
A compound represented by the following Chemical Formula 4 or a salt thereof:
- in the Chemical Formula above, R is C1-4alkyl.
A compound represented by the following Chemical Formula 5 or a salt thereof:
- in the Chemical Formula above, R is C1-4alkyl.
Dependencies are inferred from the claim text.