Substituted 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)thiophene-2-carboxamide derivatives and use thereof

A compound of formula (Z)

• wherein
• X is carbon and Y is nitrogen,
• RE is hydrogen, —C(O)—NRARB, C(O)OR6, —S(O)2NH(C1-C6)-alkyl, (C1-C6)-alkyl, halo, (C6-C10)-aryl, or heteroaryl, wherein the (C1-C6)-alkyl, (C6-C10)-aryl, and heteroaryl can be substituted by one or more independently selected (C1-C4)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkyl, 4- to 7-membered heterocyclyl, (C1-C4)-alkoxy, (C3-C7)-cycloalkoxy, —SO2R4, —NR4R5, cyano, hydroxyl, or halo, wherein the (C1-C4)-alkyl, (C3-C7)-cycloalkyl, (C1-C4)-alkoxy, (C3-C7)-cycloalkyl-(C1-C3)-alkyl, and (C3-C7)-cycloalkoxy can be substituted by one or more independently selected hydroxyl, cyano, or halo,
• RA is hydrogen or —CR1R2R3,
• RB is hydrogen or (C1-C6)-alkyl,
• R1 and R2 are each independently hydrogen or (C1-C3)-alkyl, wherein the (C1-C3)-alkyl can be substituted by one or more independently selected halo,
• R3 is hydrogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, or (C3-C7)-cycloalkyl-(C1-C3)-alkyl, wherein the (C1-C6)-alkyl, (C3-C7)-cycloalkyl, or (C3-C7)-cycloalkyl-(C1-C3)-alkyl can be substituted by one or more independently selected hydroxyl, (C1-C4)-alkoxy, oxo, cyano, or halo, and wherein the (C1-C4)-alkoxy can be substituted by one or more independently selected halo,
• or
• R1 is hydrogen and R2 and R3 are joined to one another and, taken together with the carbon atom to which they are attached, form a 3- to 7-membered ring containing up to two heteroatoms selected from the group consisting of O or N, wherein the ring can be substituted by one or more independently selected hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl, oxo, cyano, or halo, and wherein the (C1-C4)-alkoxy and (C1-C4)-alkyl can be substituted by one or more independently selected hydroxyl or halo,
• RC is hydrogen, (C6-C10)-aryl, or CR4R5R7, wherein the (C6-C10)-aryl is optionally substituted by one or more independently selected (C1-C4)-alkyl, (C1-C4)-alkoxy, or halo, and wherein the (C1-C4)-alkyl and (C1-C4)-alkoxy can be substituted by one or more independently selected hydroxyl or halo,
• R4 is hydrogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, or 4- to 7-membered heterocyclyl, wherein the (C1-C6)-alkyl, (C3-C7)-cycloalkyl, or 4- to 7-membered heterocyclyl can be substituted by one or more independently selected (C1-C4)-alkyl, (C1-C4)-alkoxy, hydroxyl, oxo, cyano, or halo, wherein the (C1-C4)-alkoxy and (C1-C4)-alkyl can be substituted by one or more independently selected halo, and any nitrogen of the 4- to 7-membered heterocyclyl can be substituted by C(O)OR6 or C(O)R6,
• R5 is (C1-C6)-alkyl, (C3-C7)-cycloalkyl, cyanomethyl, (C6-C10)-aryl, (C6-C10)-aryl-(C1-C4)-alkyl, heteroaryl, or 4- to 7-membered heterocyclyl wherein:
• (i) the (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C6-C10)-aryl, (C6-C10)-aryl-(C1-C4)-alkyl, heteroaryl, or 4- to 7-membered heterocyclyl can be substituted by one or more independently selected (C1-C4)-alkyl, (C1-C4)-alkoxy, C(O)OR6, (C3-C7)-cycloalkoxy, cyano, 4- to 7-membered heterocyclyl, or halo, and wherein the (C1-C4)-alkyl and (C1-C4)-alkoxy can be substituted by one or more independently selected 4- to 7-membered heterocyclyl optionally substituted with oxo or (C1-C4)-alkyl, (C1-C4)-alkoxy, —NR′R″, or halo, and
• (ii) the (C3-C7)-cycloalkyl, (C6-C10)-aryl, (C6-C10)-aryl-(C1-C4)-alkyl, heteroaryl, or 4- to 7-membered heterocyclyl can be fused with a 4- to 7-membered heterocyclyl or (C3-C7)-cycloalkyl,
• or
• R4 and R5 are joined to one another and, taken together with the carbon atom to which they are attached, form a 3- to 8-membered monocyclic or bridged bicyclic ring containing up to two heteroatoms selected from the group consisting of O or N, wherein:
• (i) the ring can be substituted by one or more independently selected (C6-C10)-aryl-(C1-C4)-alkyl, (C6-C10)-aryl, 4- to 7-membered heterocyclyl, (C1-C4)-alkyl, (C1-C4)-alkoxy, oxo, cyano, or halo, wherein the (C1-C4)-alkyl and (C6-C10)-aryl can be substituted by one or more independently selected 4- to 7-membered heterocyclyl, (C1-C4)-alkoxy, or halo, and the nitrogen of each of the 4- to 7-membered heterocyclyl can independently be substituted by C(O)OR6 or C(O)R6, and
• (ii) the ring can be fused with (C6-C10)-aryl, heteroaryl, or 4- to 7-membered heterocyclyl, each of which is optionally substituted with one or more independently selected (C1-C4)-alkoxy or halo, or
• R6 is hydrogen or (C1-C4)-alkyl,
• R7 is hydrogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C6-C10)-aryl, or 4- to 7-membered heterocyclyl, wherein the (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C6-C10)-aryl, or 4- to 7-membered heterocyclyl can be substituted by one or more independently selected (C1-C4)-alkyl, (C1-C4)-alkoxy, oxo, cyano, or halo, wherein the (C1-C4)-alkoxy and (C1-C4)-alkyl can be substituted by one or more independently selected halo, and the nitrogen of the 4- to 7-membered heterocyclyl can be substituted by C(O)OR6 or C(O)R6,
• RD is hydrogen or (C1-C6)-alkyl, or
• RC and RD are joined to one another and, taken together with the nitrogen atom to which they are attached, form a 4- to 10-membered monocyclic or bicyclic ring containing up to three heteroatoms selected from the group consisting of O or N, and wherein the 4- to 10-membered monocyclic or bicyclic ring is optionally substituted with one or more independently selected (C1-C6)-alkyl or (C1-C4)-alkoxy,
• Z is —NHRF or H,
• RF is hydrogen or (C1-C6)-alkyl, wherein the (C1-C6)-alkyl is optionally substituted with one or more independently selected-NR′R″,
• each occurrence of R′ and R″ is selected from hydrogen and (C1-C4)-alkyl, or R′ and R″, joined to one another and, taken together with the nitrogen atom to which they are attached, form a 3-6 membered heterocyclyl,
• RG is hydrogen or halo,
• RH is hydrogen, halo, or (C1-C4)-alkyl,
• and salts, solvates, and solvates of salts thereof.