RAS inhibitors and methods of using the same

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• ring A is a 4-12 membered heterocyclic ring, optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, cyano, oxo, C1-4-alkyl, C2-4-alkynyl, C1-4-heteroalkyl, C3-8-cycloalkyl, -C0-4-alkyl-C(O)N(R6d)2, and —C0-4-alkyl-C(O)OR6d;
• and/or wherein two substituents on the same atom of ring A may form a 3- to 5-membered ring together with the carbon atom on which they are attached;
• and/or wherein two substituents on adjacent atoms of ring A may form a 3- to 6-membered ring together with the carbon atoms on which they are attached;
• wherein the C1-4-alkyl, C2-4-alkynyl, C1-4-heteroalkyl or C3-8-cycloalkyl may be optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, —OR6d, cyano, and oxo;
• R1 is selected from the group consisting of
• L is selected from the group consisting of a direct bond, -N(R6d)-, -C(O)N(R6d)—, —S(O2)N(R6d)-, and —O—;
• R2a is a direct bond, C1-4-alkylene, C1-4-heteroalkylene, C3-8-cycloalkylene, 3- to 8-membered heterocycloalkylene, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, wherein the C1-4-alkylene, C1-4-heteroalkylene, C3-8-cycloalkylene, 3- to 8-membered heterocycloalkylene, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl each is optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, carboxyl, -OR6d, oxo, cyano, C3-8-cycloalkyl, C1-4-alkyl, C1-4-heteroalkyl, and 3- to 8-membered heterocycloalkyl;
• Y is selected from the group consisting of a direct bond, unsubstituted or substituted C1-4-alkyl, unsubstituted or substituted C1-4-alkylene, unsubstituted or substituted C1-4-heteroalkyl, —N(R6d)—, —NR6dC(O)—, —C(O)NR6d—, —NR6dC(O)NR6d—, -S(O2)NR6d—, and —NR6dS(O) 2—;
• R2b is H, C1-4-alkyl, C1-4-heteroalkyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, wherein the C1-4-alkyl, C1-4-heteroalkyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, 6- to 10-membered aryl, or 5-to 10-membered heteroaryl is each optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, carboxyl, —OR6d, oxo, cyano, -N(R6d)2, C3-8-cycloalkyl, C1-4-alkyl, C1-4-heteroalkyl, and 3- to 8-membered heterocycloalkyl;
• R3 is
• R4 is H, C1-6-alkyl, C1-6-heteroalkyl, C1-6-haloalkyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, —OC1-6-haloalkyl, —NH(C1-6-alkyl), or —N(C1-6-alkyl)2, wherein the C1-6-alkyl, C1-6-heteroalkyl, C1-6-haloalkyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, or —OC1-6-haloalkyl is each optionally substituted with one or more substituents selected from the group consisting of C1-4-alkyl, C1-4-heteroalkyl, halo, cyano, hydroxyl, ether, —N(R6d)2, and C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl,
• R5 is H, C1-6-alkyl, C1-6-heteroalkyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, wherein the C1-6-alkyl, C1-6-heteroalkyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl is each optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, carboxyl, cyano, —OR6d, —N(R6d)2, C3-8-cycloalkyl, C1-4-alkyl, C1-4-heteroalkyl, 3- to 8-membered heterocycloalkyl, 6-membered aryl, and 5- to 6-membered heteroaryl, or an R5 and R7 taken together with the atom to which they are attached form a 5- or 6-membered monocyclic ring system or a bicyclic system, wherein the bicyclic system is a 9- or 10-membered heterocyclic ring system;
• R6, R6a and R6b are each independently H, halo, cyano, C1-6-alkyl, C1-6-heteroalkyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, C3-8-aryl, or C3-8-heteroaryl, wherein the C1-6-alkyl, C1-6-heteroalkyl, C3-8-cycloalkyl, 3- to 8-membered heterocycloalkyl, C3-8-aryl, or C3-8-heteroaryl each is optionally substituted with one or more substituents selected from halo, hydroxy, cyano, —N(R6d)2, —OR6d, C1-4-alkyl, 3- to 8-membered heterocycloalkyl, and C1-4-heteroalkyl;
• R6c is H, halo, cyano, C1-6-alkyl, C1-6-heteroalkyl, C3-8-cycloalkyl, or 3- to 8-membered heterocycloalkyl, wherein the C1-6-alkyl, C1-6-heteroalkyl, C3-8-cycloalkyl, or 3- to 8-membered heterocycloalkyl is each optionally substituted with one or more substituents selected from halo, cyano, —OR6d, hydroxy, and C1-4-heteroalkyl;
• R6d is independently at each occurrence selected from the group consisting of H, cyano, C1-6-alkyl, C1-6-heteroalkyl, C3-8-cycloalkyl, and 3- to 8-membered heterocycloalkyl;
• and
• R7 is H, C1-6-alkyl, C1-6-heteroalkyl, or C3-8-cycloalkyl, wherein the C1-6-alkyl, C1-6-heteroalkyl, or C3-8-cycloalkyl is each optionally substituted with one or more substituents selected from the group consisting of halo, cyano, hydroxyl, carboxyl, —OR6d, —N(R6d)2, C3-8-cycloalkyl, C1-4-alkyl, C1-4-heteroalkyl, and 3- to 8-membered heterocycloalkyl.