Compounds and methods for targeting pathogenic blood vessels
AssigneesThe Regents of the University of California, Atengen, Inc.
InventorsHui Sun, Pu Sun, Guo Cheng, Adrian Chichuen Au, Ming Zhong
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Abstract
The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessels. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.
Claims11
A compound of Formula (I):
- or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or tautomer thereof;
- wherein
- n is 0, 1, 2, 3 or 4;
- R1 is
- each of s, t, u, v, p and q is independently 0, 1, 2, or 3, provided that the sum of s and t is 1, 2, 3 or 4, the sum of u and vis 1, 2, 3 or 4, and the sum of p and q is 1, 2, 3 or 4;
- y is 1;
- z is 0 or 1;
- Z1 is CH or N;
- Z2 is CH or N;
- Z3 is CH or N;
- Z4 is CH or N;
- Z5 is CH2, CHR25, CR25R25, C(═O), NR25, O, or S(O)0-2;
- each R25 is independently H, halo, alkyl or hydroxyalkyl;
- n is 0, 1, 2, 3, or 4;
- R2 is C2-40 alkoxy,
- R5, R7, and R8 are each independently hydrogen;
- R6 is haloalkoxy, sulfoxido, or sulfonyl;
- and
- each R9 is independently selected from halo, alkyl, —OH, alkoxy, —CN, and amino.
A compound of Formula (XII):
- or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or tautomer thereof;
- wherein:
- R1 is
- each of s, t, u, v, p and q is independently 0, 1, 2, or 3, provided that the sum of s and tis 1, 2, 3 or 4, the sum of u and v is 1, 2, 3 or 4, and the sum of p and q is 1, 2, 3 or 4;
- y is 1;
- z is 0 or 1;
- Z1 is CH or N;
- Z2 is CH or N;
- Z3 is CH or N;
- Z4 is CH or N;
- Z5 is CH2, CHR25, CR25R25, C(═O), NR25, O, or S(O)0-2;
- each R25 is independently H, halo, alkyl or hydroxyalkyl;
- R211 is C2-40 alkyl, C2-40 alkenyl, or C2-40 alkynyl;
- R6 is haloalkoxy, sulfoxido, or sulfonyl;
- and
- R91 and R92 are independently selected from H and halo.
Dependencies are inferred from the claim text.