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US 12,612,377 B2Granted
Process for preparing aminofuranes
AssigneeBayer Aktiengesellschaft
InventorsSergii Pazenok, Winfried Etzel
Life of this patent
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Abstract
The present invention relates to a novel method for preparing 4-aminofurans of the general formula (I) and salts thereof.
Claims19
A method for preparing a compound of formula (I) and/or salt thereof,
- in which
- R1 is CF3, CF2H, CCl3, COOCH3, COOC2H5, and
- R2 is H, COCF3, COCH3, COCCl3, phenyl-CH2, (diphenyl)CH, CH3OCO, (CH3)3COCO,
- comprising converting a compound of formula (II)
- in which
- R3 and R4 are each independently H and or CH3,
- and
- R1 has the definitions specified above,
- with aid of an amine of formula R5—NH2 (V) to a compound of formula (III)
- in which
- R5 is H,
- and then reacting said compound of formula III in presence of a dehydrating reagent to give a compound of formula (I).
9 more elements
A method for preparing a compound of formula (I) and/or salt thereof,
- in which
- R1 is CF3, CF2H, C2F5, CF2Cl, CCl3, COO(C1-C4)alkyl, or COOH,
- R2 is H, CH3CO, CCl3CO, CF3CO, phenyl-CO, CH3OCO, (CH3)3COCO, phenyl, phenyl-CH2, or (diphenyl)CH,
- comprising converting a compound of formula (II)
- in which
- R3 and R4 are each independently H or C1-C4-alkyl,
- and
- R1 has the definitions specified above,
- with aid of an amine of formula R5—NH2 (V) to a compound of formula (III)
- in which
- R5 is H, phenyl, phenyl-CH2, or (diphenyl)CH,
- and then reacting said compound of formula III in presence of a dehydrating reagent to give a compound of formula (I),
- wherein the dehydrating reagent comprises at least one compound selected from the group consisting of SOCl2, POCl3, PCl3, phosgene, diphosgene, triphosgene, ClCOCOCl, (CF3CO)2, P4O10, SO2F2, and HCL, or comprises a mixture of trimethyl orthoformate and triethyl orthoformate.
10 more elements
Dependencies are inferred from the claim text.