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US 12,612,366 B2Granted
Salts and crystal forms of omecamtiv mecarbil
AssigneeAmgen Inc.
InventorsHenry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao
Life of this patent
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Abstract
Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
Claims17
An omecamtiv mecarbil tartrate crystalline salt form which is any one of the following forms:
- i) an omecamtiv mecarbil bis-tartrate crystalline salt form A, characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 4.20, 7.49, 8.22, 11.88, 16.42, and 21.19±0.2° 2θ using Cu Kα radiation;
- ii) an omecamtiv mecarbil bis-tartrate crystalline salt form B, characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 3.77, 5.69, and 10.07±0.2° 2θ using Cu Kα radiation;
- iii) an omecamtiv mecarbil bis-tartrate crystalline salt form C, characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 3.57, 6.23, and 15.84±0.2° 2θ using Cu Kα radiation;
- or
- iv) an omecamtiv mecarbil mono-tartrate crystalline salt form D, characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 9.77 and 15.40±0.2° 2θ using Cu Kα radiation.
2 more elements
Dependencies are inferred from the claim text.