Method for the production of musk fragrance ingredient
AssigneeGivaudan SA
InventorsMarc Biermann, Fabian Ruethi, Marco Bocola, Haibin Chen, Kuifang He, Shumin Shi
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Abstract
A method for making intermediate compounds suitable for making muscenone, the compositions made by said methods, the various uses of said compositions, and enzyme variants useful in said methods.
Claims22
A method for making a mixture comprising a compound of formula (II), a compound of formula (III) and a compound of formula (IV),
- wherein the method comprises contacting a compound of formula (I) with an alcohol dehydrogenase,
A composition comprising a compound of formula (II), a compound of formula (III) and a compound of formula (IV),
A composition comprising a compound of formula (Va), a compound of formula (Vb) and a compound of formula (Vc),
- wherein:
- the compound of formula (Va) is present in the composition in an amount ranging from about 20.0 wt % to less than about 40.0 wt %;
- the compound of formula (Vb) is present in the composition in an amount ranging from greater than about 40.0 wt % to about 70.0 wt %;
- and
- the compound of formula (Vc) is present in the composition in an amount ranging from about 5.0 wt % to about 15.0 wt %.
A composition comprising:
- from 35 to 55% w/w of a compound of formula (Va) having an enantiomeric excess of the (R) enantiomer of less than 80%;
- from 27 to 40% w/w of a compound of formula (Vb) having an enantiomeric excess of the (R) enantiomer of less than 80%;
- from 3 to 20% w/w of a compound of formula (Vc) having an enantiomeric excess of the(S) enantiomer of less than 80%;
- and
- from 0 to 5% w/w of a compound of formula (Vd) having an enantiomeric excess of the(S) enantiomer of less than 80%
An alcohol dehydrogenase, wherein the alcohol dehydrogenase is a variant of the alcohol dehydrogenase having the amino acid sequence as set out in SEQ ID NO:
- 1, wherein the variant has at least 70% sequence identity with SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.