Adapter and method of mixing constituents of a pharmaceutical complex via an adapter

A method of mixing two constituents of a pharmaceutical complex via an adapter, the adapter comprising:

• a first port connected to a first container holding a first constituent of the two constituents;
• a second port connected to a second container holding a second constituent of the two constituents;
• a third port configured to connect to a syringe;
• wherein the adapter defines a mixing channel extending from a first end in fluid communication with the third port to a second end;
• a first transit channel that connects the first port with the mixing channel;
• a second transit channel that connects the second port with the mixing channel,
• wherein the mixing channel comprises a tortuous path along a longitudinal axis of the adapter,
• the method comprising:
• connecting the syringe comprising a plunger to the third port;
• and
• withdrawing the plunger, wherein withdrawing the plunger draws the first constituent from the first container into the first transit channel and the second constituent from the second container into the second transit channel, wherein withdrawing the plunger further draws the first and second constituent into the syringe via the mixing channel.

A method of manufacturing an adapter, the method comprising:

• forming a first depression in a first polymer piece, the first depression comprising a first discontinuous depression;
• forming a second depression in a second polymer piece, the second depression comprising a second discontinuous depression;
• and
• fusing the first polymer piece to the second polymer piece,
• wherein fusing the first polymer piece to the second polymer piece comprises offsetting the first discontinuous depression and the second discontinuous depression to define a mixing channel from a first end to a second end, the mixing channel comprises a tortuous path along a longitudinal axis of the adapter.