US 12,611,528 B2Granted

Systems and methods for draining cerebrospinal fluid

AssigneeMayo Foundation for Medical Education and Research

InventorsFredric B. Meyer, Mohamed Bydon

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Abstract

The present disclosure generally relates to systems and methods of use for draining cerebrospinal fluid (CSF) from a brain or a spinal canal in a subject, for example, to treat hydrocephalus or other conditions. In some embodiments, the disclosure relates to a device comprising a flow controller positioned within a conduit that allows CSF to flow through the conduit from a first end to a second end. This may allow the CSF to drain, for example, from an intradural space (such as a thecal sac) into, for example, a paraspinal space, paraspinal vein or other venous space, or peritoneal cavity. A variety of methods may be used to hold or anchor the device in place, for example, an expansion apparatus. In some embodiments, the device can be implanted percutaneously at a location along or within a subject's spinal column, thus reducing the need for surgery, general anesthesia, and hospitalizations.

Claims16

Dependent claims

A method of treating a subject having hydrocephalus, comprising:

puncturing a dura of the subject with a spinal needle having a hollow shaft to create an opening between intradural and epidural spaces of the subject;
delivering, from the hollow shaft of the spinal needle, a first end of a device into the intradural space of the subject, the first end of the device comprising a fluid inlet and a first expansion apparatus, wherein delivery of the first end of the device into the intradural space of the subject causes the first expansion apparatus to assume an expanded configuration, larger than the opening in the dura, in which a first segment of the first expansion apparatus extends radially outward from the fluid inlet and a second segment of the first expansion apparatus extends proximally from the first segment of the first expansion apparatus so as to be positioned proximate an intradural side of the dura around the opening in the dura;
delivering, from the hollow shaft of the spinal needle, a second end of the device into the epidural space of the subject, the second end of the device comprising a fluid outlet and a second expansion apparatus, wherein delivery of the second end of the device into the epidural space of the subject causes the second expansion apparatus to assume an expanded configuration larger than the opening in the dura;
withdrawing the spinal needle from the subject;
and
draining cerebrospinal fluid from the intradural space of the subject to the epidural space of the subject via the device.

3 more elements

A method of draining excess cerebrospinal fluid from a brain or spinal column in a subject, the method comprising:

puncturing a dura of the subject with a spinal needle having a hollow shaft to create an opening between intradural and epidural spaces of the subject;
delivering, from the hollow shaft of the spinal needle, a first end of a device into the intradural space of the subject, the first end of the device comprising a fluid inlet and a first expansion apparatus, wherein delivery of the first end of the device into the intradural space of the subject causes the first expansion apparatus to assume an expanded configuration, larger than the opening in the dura, in which a first segment of the first expansion apparatus extends radially outward and distally from the fluid inlet and a second segment of the first expansion apparatus extends proximally from the first segment of the first expansion apparatus so as to be positioned proximate an intradural side of the dura around the opening in the dura,
wherein the device is configured to control a volumetric flow rate of fluid between the first and second ends;
delivering, from the hollow shaft of the spinal needle, a second end of the device into the epidural space of the subject, the second end of the device comprising a fluid outlet and a second expansion apparatus, wherein delivery of the second end of the device into the epidural space of the subject causes the second expansion apparatus to assume an expanded configuration, larger than the opening in the dura,
withdrawing the spinal needle from the subject;
and
draining cerebrospinal fluid from the intradural space of the subject to the epidural space of the subject via the device.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/443,647Filed 16 Feb 2024 · continuation
Priority: 29 Apr 2022
Published: US 2024/0189554 A113 Jun 2024
Granted: 28 Apr 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61M 27/006
Implant devices for drainage of body fluids from one part of the body to another: cerebrospinal drainage; Accessories therefor, e.g. valves
A61B 17/0057
Surgical instruments, devices or methods: implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel…
A61F 2/01
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting…:…
A61F 2250/0051
Having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within…:…

Family

Application63/337,019Us provisional application · filed 29 Apr 2022
Application18/140,050Parent of this continuation · filed 27 Apr 2023
US 2024/0189554 A1Pre-grant publication · published 13 Jun 2024
US 11,938,290 B2Parent of this continuation
US 2023/0364395 A1Published application
US 12,611,528 B2This patent

From the US filing history. Foreign family members aren’t listed.