Accurate, precise microliter dosing syringe

A single dose syringe comprising:

• a barrel;
• a delivery conduit;
• a plunger seal disposed within the barrel;
• and
• a plunger rod assembly affixed to an end of the barrel for advancing the plunger seal within the barrel to deliver a dose of a drug through the delivery conduit, the plunger rod assembly comprising:
• a housing mounted on the end of the barrel,
• a plunger rod disposed at least partially in the housing, and
• a rotational component configured to engage at least one protrusion of the plunger rod until a start of dose delivery position is reached,
• wherein a rotational user input to the rotational component initiates translation of the plunger seal in a direction parallel to an axis of rotation of the rotational component and towards the start of dose delivery position via engagement between the rotational component and the at least one protrusion until the start of dose delivery position is reached, an axial user input to the plunger rod delivers the dose, and completion of the dose delivery is defined by an abutment between the plunger rod and the housing.