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US 12,611,491 B2Granted
Use of nanocrystals for drug delivery from a balloon
AssigneeBoston Scientific Scimed, Inc.
InventorsAiden Flanagan, Jan Weber, John Clarke
Life of this patent
Estimating the term…
Abstract
A drug delivery balloon (10) has a drug thereon in the form of crystalline particles (12), the drug having a predetermined size distribution. Optionally marker particles (14, 16) are also provided. A texturized coating (18), a cap layer (20) and/or other methods may be used to increase particle loading capacity of the balloon.
Claims14
A medical device, comprising:
- a catheter shaft;
- a balloon coupled to the catheter shaft, the balloon having an outer surface;
- a drug disposed on the outer surface;
- wherein the drug comprises crystalline drug particles mixed with a water-soluble excipient;
- wherein the water-soluble excipient includes acetyl tri-butyl citrate;
- and
- wherein the crystalline drug particles have a particle size in the range of from 0.01 μm to 2 μm.
4 more elements
A drug delivery balloon catheter, comprising:
- a catheter shaft;
- a balloon coupled to the catheter shaft, the balloon having a balloon wall with an outer surface;
- a drug coating disposed along the outer surface;
- wherein the drug coating comprises crystalline particles and a water-soluble excipient material;
- wherein the water-soluble excipient includes acetyl tri-butyl citrate;
- and
- wherein the crystalline particles have a particle size in the range of from 0.01 μm to 2 μm.
4 more elements
A drug delivery balloon adapted for delivery of a drug to a site in a body passageway, the drug delivery balloon comprising:
- a balloon wall with an outer surface;
- a drug disposed on the outer surface;
- wherein the drug is provided on the balloon as crystalline particles of the drug having a particle size in the range of from 0.01 μm to 2 μm;
- and
- wherein the crystalline particles are present in mixture with acetyl tri-butyl citrate a citrate ester.
2 more elements
Dependencies are inferred from the claim text.